Director, Target ID and Validation
Location
Cambridge, MA | United States
Job description
Why join us?
FogPharma is a clinical-stage biopharmaceutical company that seamlessly integrates breakthroughs in bench science and data science to create transformative precision therapeutics for patients suffering from devastating and often fatal diseases such as cancer. FogPharma's discovery engine creates Helicon™ therapeutics, which are a new generation of ultra-diverse, highly tunable peptide drugs capable of modulating virtually any protein implicated in disease. Our robust and wholly owned pipeline of programs is currently focused on cancer targets that are intractable to small molecules and biotherapeutics.
The company's lead program, FOG-001, is a long sought-after blocker of β-catenin:TCF interactions that is currently being evaluated in a Phase 1/2 clinical trial in patients with Wnt/β-catenin signaling pathway-activated solid tumors, including colorectal cancer. FogPharma has raised more than $350 million to date from top investors and is led by an experienced team of industry experts. FogPharma is headquartered in Cambridge, MA.
What's the opportunity?
This is an exciting opportunity to take a high impact leadership role in bringing a new and potentially transformational drug modality to patients in need. In this newly created role, you'll play a key role in driving our early discovery programs, leading a small cross-functional team of both internal and external scientists to propose and evaluate new targets for our pipeline. Your efforts will be dedicated to new target ID and validation, coordinating target evaluation and selection among multiple internal teams and colleagues, followed by execution of relevant validation studies. The matrixed nature of this role provides a unique opportunity to broaden scientific expertise, interface with senior leadership, and have a key voice in our portfolio strategy. Specifically:
- Coordinate and interface between biology, platform, data science, BD and commercial teams to ideate and nominate new targets for entry into the Fog pipeline
- Ideate new target proposals and evaluate incoming new target ideas with relevant internal stakeholders
- Oversee and drive target validation with internal direct reports, matrixed support and external support
- Strategize with senior management and leadership team to build a portfolio of programs for long-term growth and success of the company
What you'll need to be successful: - PhD in Cancer Biology or related field with 10+ years industry experience with a minimum of 5+ years of program and people management experience
- Significant experience with oncology (and beyond) target identification and validation
- Demonstrated success in leading drug development programs, driving to development candidate selection, and executing multiple, parallel deliverables and milestones.
- Enthusiastic and innovative mindset with the ability to thrive in a dynamic and highly collaborative environment.
- Excellent communication, organization, multi-tasking, flexibility, and team skills.
- Experience and passion for mentoring and developing junior scientists in target selection and drug discovery strategies
- Experience interfacing with computational biology and data science teams a plus
- Experience with peptide therapeutics a plus, but not required
- Able to work on-site and attend in-person meetings (Fog employees are required to be fully vaccinated to attend in-person work-related activities. Reasonable Accommodations will be made for individuals with a sincerely held religious belief or disability who are not vaccinated)
Core Values FogPharma is a team of passionate pioneers who are trailblazing the future of precision medicine with the aim of making a meaningful difference in the lives of patients. The company is committed to promoting an inspiring and flourishing working environment for all employees across the business, in all departments, and driving innovation for patient benefit.
- Creative . We are creating a whole new class of medicine requiring creativity to solve challenges as they arise, which we have successfully done since the inception of the company.
- Patient-focused. We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.
- Execution-oriented. As we begin clinical development and large-scale manufacturing, the team is balancing creativity and nimbleness with relentless, rigorous and flawless execution.
- Humble . We fully appreciate that science and technology and policy are in flux, and we balance deep experience with humility to ask fundamental questions and seek newly available solutions.
As an equal opportunity employer, Fog values diversity and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.
30 Acorn Park Drive | Cambridge, MA 02140 |
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