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Location

Cambridge, MA | United States

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Job description

Job Description

About This Role

Biogen is looking for a skilled and highly motivated mass spectrometry scientist to join our Bioassays and High-Throughput Screens (BHTS) group within the Biotherapeutics and Medicinal Sciences (BTMS) department in Cambridge, MA. This research fellow position will be an 18-month assignment. The BHTS mass spectrometry team provides expertise and utilizes the cutting-edge liquid chromatography-mass spectrometry (LC-MS) and high throughput MS platforms for robust and high throughput assays and screens for small molecule drug discovery. This position requires demonstrated experience in LC-MS techniques to support small molecule, intact protein (covalent binding) screens, and effectively work in a cross-functional environment to build successful partnerships across teams. The successful candidate will be an expert in the field of mass spectrometry and analytical chemistry with the implementation of these tools towards developing high throughput MS-based assays and screens.

What You’ll Do

• Develop and validate LC-MS methods for various small and large molecule (peptide, protein) entities
• Develop, run, and troubleshoot physiologically relevant cell-based and biochemical assays to identify and characterize small-molecule binders/modulators using LC-MS or SPE MS
• Deliver high-quality MS-based data and provide data analysis/interpretation for appropriate decision-making
• Responsible for recording all experiments/tasks in electronic notebooks to comply with applicable regulatory standards
• Present at internal/external meetings and publish in peer-reviewed scientific journals

Qualifications

Who You Are

You are an expert in the field of mass spectrometry. You are passionate about implementing your expertise to support early stage small molecule drug discovery projects.

Required Skills

• Ph.D. in a relevant scientific field (i.e., analytical chemistry, biological sciences, biochemistry, pharmaceutical sciences, or molecular biology)
• Significant experience with chromatographic separation of various analytes by LC and characterization and quantification by MS or MS/MS
• Extensive direct experience with biological sample preparation and biochemical techniques

Preferred Skills

• Expertise in high resolution mass spectrometry systems (orbitrap, TOF)
• Familiarity with methods and instruments for automated plate-based assays and the use of relevant liquid handlers
• Demonstrated experience in developing and validating MS-based quantitative assays for small or large molecules
• Experience in development of computational methods for processing mass spectrometry data

Additional Information

Why Biogen?

Our mission to find therapies for neurological and rare diseases is a unique focus within our industry and this shared purpose is what connects us as a team. We work together to overcome obstacles and to follow the science. We are resilient as we strive to make an impact on our patients’ lives and on changing the course of medicine. Together, we pioneer. Together, we thrive.

At Biogen, we are committed to building on our culture of inclusion and belonging that reflects the communities where we operate and the patients we serve. We know that diverse backgrounds, cultures, and perspectives make us a stronger and more innovative company, and we are focused on building teams where every employee feels empowered and inspired. Read on to learn more about our DE&I efforts.

All qualified applicants will receive consideration for employment without regard to sex, gender identity or expression, sexual orientation, marital status, race, color, national origin, ancestry, ethnicity, religion, age, veteran status, disability, genetic information or any other basis protected by federal, state or local law. Biogen is an E-Verify Employer in the United States.

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