Work In Biotech
Location
South San Francisco, CA | United States
Job description
At Lyterian Therapeutics , we are committed to developing medicines for patients in need by co-opting physiologically-relevant protein homeostatic mechanisms to regulate genetically-validated targets.
As Senior/Principal Scientist, Proteomics you will be part of a highly collaborative, interdisciplinary team, and will be responsible for characterizing proteins and protein complexes relevant to our protein homeostasis drug discovery platform and programs. You will design assays, drive innovative technologies, and lead projects using mass spectrometry-based proteomic studies to inform and streamline early-stage research and clinical discovery programs. By collaborating with chemists, biochemists, biophysicists, structural biologists, bioinformaticians, and molecular biologists, you will uncover the cellular machinery that participates in chemically-induced protein homeostasis and define the fundamental biology that drives therapeutic efficacy. We look for team members who are inspired by our mission and want to work in a collaborative, rigorous, and entrepreneurial environment. We seek colleagues who are self-motivated, innovative, proactive, and possess an innate curiosity to discover novel biology and new drugs. Efficient time management, excellent organizational and communication skills, and passion for high-quality, translational science are essential.Impact You'll Make:
Lead, design, execute, and interpret projects to study proteins and protein complexes using mass spectrometry-based proteomics approaches
Establish and lead a cutting-edge, on-site proteomics facility and eventually grow your group by hiring and mentoring team members
Develop and implement robust workflows for sample preparation, LC-MS-based proteomics, and quantitative data analysis
Collaborate with cross-functional research teams to design and execute proteomic and other biological mass spectrometry experiments and generate high quality data to progress drug discovery and development projects
Provide or coordinate day-to-day instrument operation, maintenance, quality control and troubleshooting of Orbitrap mass spectrometers and nano-flow high performance chromatography systems (nHPLC)
Serve as the scientific leader and subject matter expert (SME) in proteomics and mass spectrometry on multiple project teams
Develop and contribute to our company's intellectual property (IP) domain by way of patents and/or publications, often as principal author
Stay up-to-date with emerging scientific literature and share your ideas liberally, present and actively discuss data
Collaborate and communicate across a diverse scientific team to successfully progress Lyterian goals
Qualifications:
PhD in Chemical Biology, Proteomics, Biology, Biochemistry, Biophysics or related discipline with 5+ years of relevant postdoctoral or industrial experience
Experience using mass spectrometry-based approaches to examine protein-protein interaction networks and post-translational modifications, with a proven track record of solving bioanalytical problems
Experience with chemoproteomic techniques and identification of site-specific small molecule modification of proteins using mass spectrometry
Experience with quantitative proteomics, including techniques such as SILAC, SRM, TMT, label-free quantification approaches, ABPP, IP-MS, etc.
Expertise with both DDA and DIA acquisition techniques and analysis of large scale proteomics data using commercial and open-source software tools (Proteome Discoverer, Skyline, MaxQuant, etc…)
In-depth knowledge and demonstrated proficiency in operating nano LC-MS and Orbitrap-based MS systems is required
Develop and execute high-throughput proteomic characterization assays for recombinant and endogenous proteins, including intact mass analysis. Experience with affinity selection mass spectrometry (ASMS) screening technologies is a plus.
Knowledge of protein degradation mechanisms and in particular the biochemistry of ubiquitin ligases
Evidence of scientific excellence and impact as illustrated by scientific publications and presentations
Initiative and boldness to dive into a fast-paced new startup
$150,000 - $190,000 a year
We encourage candidates of all levels to apply as there is often flexibility on job title and responsibilities. Compensation will be based on a variety of factors, including experience, qualifications, internal equity and location. Lyterian offers a competitive employment package that includes an annual bonus, significant equity, and a generous benefits package including comprehensive health, dental, and vision insurance for our employees and their families, plus a 401K match.
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