University of Michigan
Location
Ann Arbor, MI | United States
Job description
University of Michigan, Ann Arbor, MI, United States
Employer Description
PI: Thomas D Wang, MD,PhD, University of Michigan
Project goal is to develop a robotically-assisted photoacoustic endomicroscope to perform image-guided surgery of tumor margins during intra-operative surgery.
Job Description
Post-doctoral research opportunities are available in the Wang Lab at the University of Michigan to join a highly collaborative, multi-disciplinary team to develop an end-to-end solution for an intra-operative photoacoustic imaging system to detect cancer. A multi-modal confocal photoacoustic endomicroscope will be developed to detect next generation contrast agents specific for cancer targets. The imaging prototype will be verified first in pre-clinical models and then in human subjects. Clinical studies will be performed by a highly experienced international team of surgeons in collaboration with a global leader in robotic-assisted minimally invasive surgery. The integrated solution will improve precision for tumor localization and differentiation from normal tissues to improve patient outcomes. The successful applicant will have an opportunity to design a multi-element acoustic sensor array to generate 3D volumetric images with a large field-of-view. A tunable OPO laser will be used to generate deep tissue penetration with near-infrared excitation. A multi-channel analog-to-digital converter will be developed to acquire the photoacoustic signal, and a field-programmable gate array module will be incorporated to achieve greater image acquisition speeds.
Job Requirements
Candidates with a Ph.D. in engineering (mechanical/electrical/biomedical), optics, physics, or a related discipline with hands-on experience in instrumentation, data acquisition, control, optical design, or fiber optic systems are invited to apply. Programming experience with Labview, Matlab, C++, and Solid Works is desirable. International investigators are welcome. Relevant skills include the following:
Research environment:The University of Michigan is committed to diversity and equality in education and employment, and is an ideal training ground for postdocs who want to further develop their skills in pursuit of a career in academia or industry. Salary will be commensurate with the applicant’s experience and in compliance with NIH guidelines.
The Wang Laboratory is located in the Biomedical Science Research Building (BSRB) on the University of Michigan medical campus. The facility is equipped with an Opotek Phocus laser (~150 mJ at 800 nm) with optical parametric oscillator (OPO), Edgewave diode pumped Q-switched Nd-YAG laser, and an Endra Nexus 128 photoacoustic tomography system. Ultra-fast lasers available for multiphoton imaging include a Spectra-Physics Insight X3 and Deep See Mai Tai. A number of solid state diode lasers with excitation over the visible and NIR spectrum can be used for confocal imaging. There are 4 optical tables that contain a variety of mounts, positioners, and stages for development of prototype flexible fiber-coupled endomicroscopes located in 3 laboratory modules ~450 sq ft in size. A wide range of equipment, including function generators, spectrometer, laser beam profiler, optical spectrum analyzer, oscilloscopes, photomultiplier tube (PMT) detectors, and power supplies are available for use. Software, including Zemax, Solid Works, Matlab, and Labview, is used to perform optical and mechanical simulations and data acquisition. LI-COR Pearl Trilogy NIR fluorescence, Ultrasonix ultrasound imaging system, and Olympus FV1000MPE twin multi-photon microscope. This modern biomedical optics research facility is conveniently located near the Lurie Nano Fabrication (LNF) facility, a state of the art microfabrication facility for development of miniature scan mechanisms and the Michigan Medicine Medical Procedures Unit (MPU) where the endomicroscopes are clinically translated.
Candidates should submit CV and contact information by email:
Thomas D. Wang, M.D.,Ph.D.
Professor of Medicine, Biomedical Engineering, and Mechanical Engineering
Marvin Pollard Collegiate Professor of Endoscopy Research
University of Michigan
109 Zina Pitcher Pl. BSRB 1522
Ann Arbor, MI 48109-2200
Email: [email protected]
https://sites.google.com/a/umich.edu/wang_lab
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