University of California San Diego
Location
La Jolla, CA | United States
Job description
UCSD Layoff from Career Appointment : Apply by 02/08/2024 for consideration with preference for rehire. All layoff applicants should contact their Employment Advisor.
Special Selection Applicants : Apply by 02/19/2024 Eligible Special Selection clients should contact their Disability Counselor for assistance.
Current UC San Diego Health Neurosciences employees who apply by 2/12/2024 will have priority consideration for this position. Recruiters will refer qualified internal candidates after the first 7 days of the job posting. All qualified external applicants and additional internal applicants who apply after the priority date may have further consideration pending the results of the initial review.
The Department of Neurosciences has a large research group studying neuro-degenerative diseases. Stimulated by neuropathological observations and genetic discoveries, studies in cell and animal models of neuro-degenerative disorders have begun to clarify pathogenetic mechanisms of disease. We examine the intersection of these research themes and identify several potential mechanisms for linking failed neurotrophic factor signaling to neurodegeneration. We will be expanding our research group and are looking for a Staff Research Associate to support our efforts.
Incumbent will independently perform the dissection of fresh or fixed human brains including tissue preparation and processing, for the Alzheimer's Disease and Neurodegeneration tissue/brain bank. The incumbent will perform experiments aimed at understanding the molecular mechanisms involved in neurodegeneration in neurological disorders such as protein purification, protein quantification and statistical analysis. The incumbent will assist with various mouse protocols including anesthesia, husbandry, sacrifice, perfusion, tissue harvesting and paraffin block embedding. Additional duties include support for the Shiley-Marcos ADRC, such as archiving and retrieving samples.
Theoretical knowledge in cell biology, chemistry and molecular genetics as typically acquired by a Bachelor's degree, or an equivalent combination of education and experience.
Ability to maintain meticulous records regarding all aspects of work performed in the lab.
Knowledge of molecular biology including: RNA/DNA isolation, Real-time PCR, bacterial transformation, Western blot, and tissue culture.
Ability with producing high quality vibratome sections for confocal microscopy.
Knowledge of neurological disorders such as Alzheimer's Disease, Parkinson's Disease and HIV.
Experience with and knowledge of the operation and maintenance of various laboratory equipment such as confocal, fluorescent, and electron microscopes, centrifuges, plate readers, microtomes, and vibratomes.
Experience preparing buffers and solutions.
Computer skills and experience with the operation of all basic software application such as Word and Excel, as well as knowledge and ability to work with a variety of statistical and analysis programs, and learn specialized imaging and analysis software.
Excellent communication skills (both verbally and written) to interact professionally and effectively in a basic research work environment, as well as accurately document research procedures that facilitate professional and effective interaction with a diverse population. Ability to comprehend and discuss research materials.
Experience performing accurate record keeping and organize and calculate data. Skill to plan and organize work assignments in a efficient and productive manner.
Excellent organizational skills, including ability to multitask. Ability to prioritize workload and to shift efforts to meet changing and demanding project and research timelines.
Excellent interpersonal skills including tact, diplomacy and flexibility. Ability to work independently and/or in a team framework in conjunction with principles of community and in a lab environment that interacts with a diverse group of research and technical personnel and other laboratories.
Knowledge of basic lab safety requirements, procedures, and ability to follow EH&S regulations and methods for handling, inventory, storing, clean-up, and waste disposal for biohazardous materials. Ability to maintain safe and orderly laboratory. Ability to maintain inventories and order supplies for lab.
Experience processing human and murine brain tissue for immunocytochemical assays and western blots.
Knowledge of UCSD Environmental Health and Safety requirements including radiation and biosafety procedures.
Basic knowledge of
About University of California San Diego
UC San Diego is an academic powerhouse and economic engine, recognized as one of the top 8 public universities by U.S. News and World Report. Innovation is central to who we are and what we do. Here, students learn that knowledge isn't just acquired in the classroom - life is their laboratory. UC San Diego's rich academic portfolio includes six undergraduate colleges, five academic divisions and five graduate and professional schools. The university's award-winning scholars are experts at the forefront of their fields with an impressive track record for achieving scientific, medical and technological breakthroughs.
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