US Food and Drug Administration
Location
Silver Spring, MD | United States
Job description
Organization: Cellular Immunology Group, Laboratory of Bacterial Polysaccharides, Center for Biologics Evaluation and Research of the US FDA (CBER/FDA).
Background: Our laboratory is investigating the immunobiological mechanisms responsible for the suboptimal vaccine responses in newborns and infants. The goal of these studies is to improve the efficacies of pediatric vaccines using adjuvants targeting the pathways responsible for the blunted immune responses.
Project description: We are using neonatal mice from immunocompetent as well as various transgenic backgrounds to study the immune responses to diverse vaccine platforms including mRNA vaccines (SARS-CoV-2) and novel delivery systems. The analysis of immune response involves detailed investigation of the cellular and molecular mechanisms controlling the development of follicular helper T (Tfh) cells and germinal center B cells. The candidate will participate in experimental design, immunization and analyzing cellular and molecular responses to vaccines in addition to writing manuscripts and presenting her/his work in national and international meetings.
Qualifications:
Location/Facilities: The laboratory, located on the White Oak Campus in building 52/72 (Silver Spring, MD), is equipped with standard immunology, biochemistry and molecular biology equipments. CBER core facilities include Flow cytometry, Microscopy and Imaging, NextGen sequencing, Oligonucleotide synthesis, Peptide synthesis, Mass spectrometry analysis, among others.
How to apply: Qualified candidates should send curriculum vitae and a list of 3 references with contact information to Mustafa Akkoyunlu, [email protected]
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