Oak Ridge National Laboratory
Location
Oak Ridge, TN | United States
Job description
Requisition Id 12263
Overview
As a U.S. Department of Energy (DOE) Office of Science national laboratory, ORNL has an extraordinary 80-year history of solving the nation’s biggest problems. We have a dedicated and creative staff of over 6,000 people! Our vision for diversity, equity, inclusion, and accessibility (DEIA) is to cultivate an environment and practices that foster diversity in ideas and in the people across the organization, as well as to ensure ORNL is recognized as a workplace of choice. These elements are critical for enabling the execution of ORNL’s broader mission to accelerate scientific discoveries and their translation into energy, environment, and security solutions for the nation.
The Diffraction Group in the Neutron Scattering Division (NSD) at Oak Ridge National Laboratory (ORNL) has an immediate opening for a Postdoctoral Research Associate in macromolecular X-ray and neutron crystallography and neutron vibrational spectroscopy to investigate the structure-dynamics-function relationships of enzymes and enzyme-ligand complexes involved in disease, including proteases from RNA viruses such as HIV-1, SARS-CoV-2, norovirus, and dengue fever virus. In this position, you will be expected to contribute to the development of methodology for investigating the structure and dynamics of enzymes involved in disease using X-ray diffraction, neutron diffraction, inelastic neutron scattering and molecular simulations and will participate in structure-assisted drug design utilizing standard approaches, VR and AI tools in collaboration with computational scientists. You will join a multi-disciplinary research team that is developing and applying isotopic labeling, neutron diffraction and scattering techniques to understand and control the structure, function, and dynamics of drug targets. As an ORNL postdoctoral fellow you will have access to state-of-the-art facilities for isotopic labeling, biophysical characterization, and X-ray diffraction, as well as access to world class facilities for neutron diffraction and scattering, and molecular simulations. The position will allow the postdoctoral scientist to develop expertise, broaden experience and interact with a diverse set of scientists working at the ORNL’s neutron, nanomaterial science and high-performance computing facilities.
Desirable skills include expertise in biological structure determination including protein-ligand complexes, protein expression/purification/crystallization, molecular simulations, and some ability to code in Python. You will also have access to a suite of biophysical characterization tools, as well as external synchrotron facilities.
This position will report to Andrey Kovalevsky. You will work closely with research staff and other postdoctoral associates in NSD and across ORNL.
Major Duties/Responsibilities:
Basic Qualifications:
Preferred Qualifications:
Provide a current curriculum vitae including a list of publications when applying for this position. You can upload these directly to your application or have them sent to [email protected] with the position title and number referenced in the subject line. If you are selected for interview, you will be required to send in a minimum of two letters of reference.
Please include a discussion of your research interests and how neutron scattering can support your plan for research during your time at ORNL in your cover letter with your application.
Instructions to upload documents to your candidate profile:
Applicants cannot have received their Ph.D. more than five years prior to the date of application and must complete all degree requirements before starting their appointment. The appointment length will be for up to 24 months with the potential for extension. Initial appointments and extensions are subject to performance and the availability of funding.
Benefits at ORNL:
ORNL offers competitive pay and benefits programs to attract and retain talented people. The laboratory offers many employee benefits, including medical and retirement plans and flexible work hours, to help you and your family live happy and healthy. Employee amenities such as on-site fitness, banking, and cafeteria facilities are also provided for convenience.
Other benefits include: Prescription Drug Plan, Dental Plan, Vision Plan, 401(k) Retirement Plan, Life Insurance, Pet Insurance, Generous Vacation and Holidays, Parental Leave, Legal Insurance with Identity Theft Protection, Employee Assistance Plan, Flexible Spending Accounts, Health Savings Accounts, Wellness Programs, Educational Assistance, Relocation Assistance, and Employee Discounts.
If you have difficulty using the online application system or need an accommodation to apply due to a disability, please email: [email protected].
This position will remain open for a minimum of 5 days after which it will close when a qualified candidate is identified and/or hired.
We accept Word (.doc, .docx), Adobe (unsecured .pdf), Rich Text Format (.rtf), and HTML (.htm, .html) up to 5MB in size. Resumes from third party vendors will not be accepted; these resumes will be deleted and the candidates submitted will not be considered for employment.
If you have trouble applying for a position, please email [email protected].
ORNL is an equal opportunity employer. All qualified applicants, including individuals with disabilities and protected veterans, are encouraged to apply. UT-Battelle is an E-Verify employer.
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