Bristol Myers Squibb Careers
Location
Cambridge, MA | United States
Job description
Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.
Bristol-Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases. We are passionate about making an impact on the lives of patients through research. This open position offers the opportunity to join a vibrant and collaborative research community striving to find new disease targets and develop innovative therapies.
This is an exciting opportunity to develop cutting-edge and diverse high-throughput functional genomic and CRISPR screening technologies to aid in the discovery and advancement of early-stage therapeutic targets in the context of solid tumor cancer resistance mechanisms. The selected candidate will join the Early Target Biology group within the Mechanisms of Cancer Resistance Thematic Research Center at the new Cambridge Crossing site. The site is highly collaborative and the candidate will have exposure to all stages of drug discovery as part of their growth and development.
Core Job Functions - Develop and implement high-throughput, functional genomics screening assays (such as genome-wide CRISPR screens, digenic screens, protein tiling screens) with potential to implement advanced genomics technologies as part of a highly collaborative project team.
- Validate novel targets arising from screening efforts using a variety of mammalian cell-based assays
- Collaborate with data analysts and project teams across asset progression as well as in the translational research space
- Interface and coordinate with academic collaborators. Keep up to date with the latest state-of-the-art technologies in the genomics/CRISPR space.
- Organize, track and progress projects in a timely fashion.
- Independently design experiments, compile and analyze data, troubleshoot novel methods as needed, and maintain lab notebooks, protocols, and written records.
- Train and assist other team and site members.
Basic Qualifications - Bachelor’s Degree
- 5+ years of academic and / or industry experience
Or
- Master’s Degree
- 3+ years of academic and / or industry experience
Or
- Ph.D. or equivalent advanced degree in the Life Sciences
Preferred Qualifications - Strong scientific and hands-on experience with:
- High throughput gene perturbation screening techniques (such as whole genome or targeted CRISPR screens, Perturb-seq, CRISPR tiling screens, shRNA screens, deep mutational scanning, ORF screens, digenic screens, flow cytometry-based screens)
- Genome engineering techniques (gene knockout/knockdown/knock-in)
- Mammalian tissue culture, lentivirus generation, viral transduction, and transfection
- Cellular and molecular biology techniques such as RNA/DNA isolation, western blotting, flow cytometry, RT-PCR, cell proliferation assays (CTG, incucyte), molecular cloning and vector design
- Proficiency in utilizing software such as ELN, Graph Pad, Microsoft office etc. for data analysis and figure generation is required.
- Solid tumor cancer biology, CRISPR guide design, vector optimization, NGS library construction, familiarity with NGS data analysis and interpretation, high throughput assays and automation, cancer genome data mining (eg. cBioportal, Depmap)
- Attention to detail with excellent organizational and record keeping skills
- Excellent interpersonal skills with the ability to interact effectively with people, internally and externally
If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career. Uniquely Interesting Work, Life-changing Careers With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
On-site Protocol Physical presence at the BMS worksite or physical presence in the field is a necessary job function of this role, which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and it enhances the Company culture.
BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to
[email protected]. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.
BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.
BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.
Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.
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