Scientist / principal scientist

Location

South San Francisco, CA | United States

Job description

Sr. Scientist / Principal Scientist, Protein Purification and Analytics

February 2024

Department: Technology Job Code : 11

Work Location

Corporate Headquarters (South San Francisco)

Position Summary

TCG Labs-Soleil is seeking an experienced and motivated research scientist to join our Biologics team to implement efficient cloning and expression capabilities in support of a highly productive therapeutic antibody discovery and engineering team. The successful candidate will have extensive skills in molecular biology and experience in expression and purification of recombinant proteins using mammalian transient and stable systems. As part of an interdisciplinary research team, the selected individual will be a key contributor to the progression of an exciting and diverse therapeutic pipeline.

Responsibilities

• Establish and develop efficient high throughput molecular biology capabilities to generate DNA constructs for transient and stable mammalian cell expression of antibodies and proteins to support therapeutic discovery and engineering efforts
• Build consistent and robust protein expression capabilities for both transient and stable 293 and CHO cells that encompass HTP small scale through gram level protein production
• Evaluate and implement bacterial and insect expression systems as needed
• Contribute to the R&D protein purification workflows at multiple scales with particular focus on developing efficient high throughput small scale purification processes
• Develop and implement methods/processes for automating small-scale antibody production
• Serve as subject matter expert in protein sciences

Qualifications

• PhD in Biochemistry, Cell biology or similar with a minimum of 3-6 years of relevant experience, or Masters / Bachelor’s with comparable experience.
• Strong expertise in the design and assembly of DNA constructs for antibody and protein expression, including construct design, mutagenesis, sequence analysis. Experience with high throughput cloning methods such as Gibson or Gateway is a plus
• Significant experience in recombinant protein and antibody expression using 293 and CHO cells is preferred, with both transient and stable expression ideal
• Prior experience with small scale shake flasks or tubes is a must, with experience using bench-top bioreactors a plus
• Demonstrated strong experience in protein purification using AKTA
• Skilled in implementing automation to enable efficient Ab discovery workflows is preferred
• Experienced in providing technical training, guidance, and leadership to direct reports and teammates in discovering therapeutic candidate antibodies.
• Strong communication skills.
• Ability to prepare, present and discuss project reports in internal project teams

Company Overview

TCG Labs-Soleil, established in partnership with The Column Group, a science-focused venture capital firm, is pioneering a novel ‘venture capital-biotech’ model. Our core mission is to efficiently translate scientific insights into therapeutic solutions for patients facing serious diseases. This model supports scientific entrepreneurs from the initial idea to clinical proof of concept (PoC) by combining a dedicated fund (TCG Labs) with our independent, evergreen R&D center led by a top-tier scientific team (Soleil). Together, we create an integrated ecosystem that fosters the development of single-asset portfolio companies, strategically poised for transacting after clinical PoC.

For more details, visit TCGLSoleil.com and follow us on LinkedIn

EEO Statement

TCG Labs-Soleil is an Equal Opportunity Employer. We do not discriminate against qualified applicants based upon any protected group status, including but not limited to race, religion, color, creed, sex (including breastfeeding and related conditions), gender identity/gender expression, pregnancy (including childbirth and related conditions), national origin, ancestry, age, marital status, military or veteran status, sexual orientation, genetic information, physical or mental disability or medical condition as defined by applicable equal opportunity laws. Any request for accommodation can be directed to [email protected].

Benefits and Compensation

TCG Labs-Soleil provides a competitive benefits package that includes access to Medical, Dental, and Vision Insurance, Life Insurance, Short and Long Term Disability, Health Savings Account (HSA), Flexible Spending Accounts (FSA), 401k plan and PTO.

The anticipated salary range for fully qualified candidates applying for this role will be $122,000 - $250,000 annually (not including discretionary bonus, equity, and benefits). The final salary offered will be dependent on several factors that include but are not limited to relevant previous experience including duration and type of experience within the industry, education, and internal equity.

Staffing Agencies

TCG Labs-Soleil does not accept unsolicited agency resumes and will not pay fees to any third-party agency or firm that doesn’t have a signed agreement with TCG Labs-Soleil. Please do not send agency CVs/resumes through TCG Labs-Soleil website or TCG Labs-Soleil Employees. Inquiries must be sent to [email protected] with the Subject Heading: Staffing Agency Request.

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