Sr. Scientist I - Sr. Principal Scientist (PRD)
Location
Longmont, CO | United States
Job description
Company Information
Cambrex is a leading global contract development and manufacturing organization (CDMO) that provides drug substance, drug product, and analytical services across the entire drug lifecycle. With over 40 years of experience and a growing team of over 2,200 experts servicing global clients from North America and European sites, Cambrex is a trusted partner in branded and generic markets for API and dosage form development and manufacturing.
At Cambrex, our people set us apart. We’re committed to attracting, nurturing, and retaining a passionate and talented team of valued experts in our fast-paced and growing company. We offer an exceptional benefits package including medical, dental, vision, Life, LTD, generous vacation in your first year, sick time, and retirement savings!
Known for our scientific and manufacturing excellence, as well as our strong customer focus, we offer a range of career opportunities across our global network of locations. Together with our customers, we aim to improve the quality of life for patients around the world.
Job Overview
Cambrex is seeking a highly motivated Sr. Scientist I - Sr. Principal Scientist for the Process Chemistry department. This position performs routine and complex organic synthesis, purification, and analytical evaluation of materials as part of a process chemistry research and development team. The chemist will optimize synthetic routes to active pharmaceutical ingredients for purity, reproducibility, scalability, and yield. Experience in process chemistry research and development is desirable. Designs and proposes new synthetic routes to drug substances. May be asked to lead process chemistry portion of customer projects and potentially a group of process chemists. Presents work internally and externally to clients or regulatory agencies.
Responsibilities
- C arry out multistep organic syntheses, isolation, and purification of targeted products independently. Contribute to the strategic approach used to optimize reactions, isolations, and purifications.
- Proficiently conduct analysis of starting materials, reaction mixtures, intermediates and products using appropriate instrumentation.
- Work closely with other chemistry and analytical laboratory staff to coordinate project activities and resource usage.
- Routinely generate summaries and reports on completed experimental work for internal and external use. Routine presentation of experimental work for internal meetings and teleconferences with customers.
- Work to ensure that teamwork and cooperation exists within the group at all times.
- Conduct laboratory operations in a safe manner. Maintain familiarity with the company’s chemical hygiene plan. Exhibit safety awareness and safe work practices.
- Follow responsible actions regarding chemical disposal. Maintain compliance with all regulations at the federal, state, and local levels.
- Address routine administrative requirements in a timely fashion.
- Demonstrate effective communication skills (both written and oral). Participate in project team meetings with customers.
- Work closely with manufacturing and GMP operations to coordinate project-related equipment and activities. Assist in the transfer of processes to the manufacturing team.
- Independently designs and proposes new synthetic processes to produce the drug substance.
- May act as process chemistry lead for customer projects. Identify critical questions to be answered and set priorities for the process chemistry team.
- Maintain familiarity with applicable literature including organic chemistry and techniques.
- Participate in setting strategy and timing needed for customer proposal requests.
- Work closely with other chemistry and analytical laboratory staff to coordinate project activities and resource usage.
- Routinely generate summaries and reports on completed experimental work for internal and external use. Oral and written presentation of experimental work for internal meetings and teleconferences with customers
- Performs other related duties as assigned.
Qualifications/Skills
- Beginning to demonstrate an understanding of advanced theories in Organic Chemistry and process development
- Higher level understanding of the principles of cross-functional departments, including analytical chemistry and engineering
- Demonstrated understanding of industrial GMP and practical application to Cambrex programs; Some ability to provide feedback to clients re: clinical strategy
- Advanced knowledge of HPLC, GC, MS, Automated reactor platforms, In-situ reaction monitoring, and ability to train and troubleshoot problems with equipment (and help others)
- Good written and oral communication skills, ability to communicate with clients without manager supervision
- Strong d emonstration of problem-solving ability to lead investigations
- Able to maintain timeline of key activities and use time efficiently; ability to handle projects without supervision though requires regular check in with manager
- Demonstrated record of mentorship and development of peers, partner lines, and ability to support initiatives within the department
- Ability to author and review key technical documents with minimal RFT errors. Can write new SOP with manager assistance, keep current lab notebook while practicing GDP
- Ability to lead local project teams and steer clients to desired outcomes; ability to work with management to develop key local laboratory-based initiatives
- Recognized scientific leader within the Cambrex organization, locally and possibly beginning to extend to other sites
- Good mentoring skills and demonstrates leadership skills
- Demonstrated ability to participate and share leadership on local OE initiatives
- Demonstrated contribution of input and ideas for larger Cambrex system level changes
Education, Experience & Licensing Requirements
PhD in Organic Chemistry with 0-12+ years of experience in related industry, or MS in Organic Chemistry with 3-18+ years of experience in related industry, or BS in Organic Chemistry with 9-24+ years of experience in related industry.
- Advanced to expert understanding of general chemistry and organic chemistry.
- Understanding of modern organic synthesis reactions, isolations, and purification procedures.
- Full understanding of common synthetic organic reaction mechanisms.
- Understanding and proficient use of all relevant analytical techniques and instrumentation such as NMR, IR, MS and HPLC.
- Expertise in laboratory glassware and organic chemistry reaction set up, isolation and purification
- Must demonstrate proficiency in synthesis and purification techniques on scales ranging from milligrams to kilograms.
- Good written and verbal communication skills
- Familiarity with computer software such as ChemDraw, Microsoft Word, PowerPoint, and Excel.
- Aptitude and willingness to gain more skills & knowledge.
- Good attention to detail and good problem-solving skills.
- Clear and concise communication skills.
- Effectively presents ideas and concepts.
- Demonstrates leadership skills.
The hiring range in Colorado for this position is $82,000 - $135,000; however, base pay offered may vary depending on job-related knowledge, education, skills and experience of the applicant, internal equity, and alignment with market data. This hiring range encompasses several levels. This information is provided per the Colorado Equal Pay Act. This position includes a competitive benefits package.
Cambrex is an Equal Opportunity / Affirmative Action employer and will consider all qualified applicants for employment without regard to race, color, religion, gender, sexual orientation, gender identity, national origin, age, protected veteran status, or disability status.
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Physical Demands: The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.
While performing the duties of this Job, the employee is regularly required to use hands to finger, handle, or feel; reach with hands and arms; talk or hear and smell. The employee is frequently required to sit. The employee is occasionally required to stand; walk and stoop, kneel, crouch, or crawl. The employee must regularly lift and/or move up to 10 pounds, frequently lift and/or move up to 25 pounds and occasionally lift and/or move up to 50 pounds. Specific vision abilities required.
Environment and Protective Equipment: The work environment characteristics described here are representative of those an employee encounters while performing the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. While performing the duties of this Job, the employee is occasionally exposed to moving mechanical parts and vibration. The noise level in the work environment is usually very quiet.
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