Principal Scientist, Medicinal Chemistry
Location
Cambridge, MA | United States
Job description
Our Culture:
Our Culture: Why work with us?
At Foghorn Therapeutics, we believe in “People First, Mission Always.”
We put “People First” because we know our people are the key to everything we will accomplish. We value the diversity of background, ideas, perspectives and experiences that our team members bring to Foghorn Therapeutics – demonstrated by our community speaking more than 22 languages and representing over 24 nationalities. We value our teammates as people, not just as employees – validated by our actions that let our people know that we care about them, their families, and their lives.
We say “Mission Always” because we know a relentless commitment to our mission will make a difference in the lives of others. We believe our success will come from evaluating the data to follow the science. We work hard to develop a new class of therapies that could improve the lives of over 2.5 million people with cancer.
Our culture is focused on succeeding through the evaluation of data, not people. And in that, relationships can flourish and develop.
Our Science:
The groundbreaking science behind our therapies continues to yield vital insights into diseases that have confounded physicians and researchers. Our core scientific approach is centered on the chromatin regulatory system, which opens and closes the right sections of DNA at the right time. Breakdowns in the chromatin regulatory system lead to a wide range of diseases, including cancer, impacting millions of people.
Our proprietary Gene Traffic Control® platform is a powerful tool for understanding and modulating the chromatin regulatory system. We are pursuing multiple treatments for breakdowns in this system. We are the only company with the ability to study and target the chromatin regulatory system at scale, in context, and in an integrated way.
The Role:
This role is an opportunity to help advance our portfolio of drug discovery projects through the design and synthesis of new chemical entities as a part of the Medicinal Chemistry Team. You will work as part of multidisciplinary teams from early discovery to the delivery of drug candidates. We have 3 world class science labs onsite. A lot of the scientific work you’re doing in this role will be lab based. At Foghorn there is opportunity to advance your career and grow within our organization.
In This Role, You’ll Get To:
- Design, plan and execute multi-step organic synthesis and purification of high-quality target molecules and solve synthetic chemistry challenges to enable expansion of available chemical space
- Analyze data sets and develop SAR using in-house and commercial in silico tools and communicate results in formal and informal settings
- Proactively seek input from computational chemistry and structural biology to collaboratively work through iterative design processes to generate novel design ideas
- Partner with CROs to enable timely delivery of target compounds
Requirements
Qualifications and skills
- MS or PhD degree in organic chemistry, in addition to 5+ years of medicinal chemistry experience in a pharmaceutical / biotechnology setting OR;
- BS degree in organic chemistry, in addition to 12+ years of medicinal chemistry experience in a pharmaceutical / biotechnology setting
- Industry experience in Oncology
- Work experience in medicinal chemistry with PROTACs, degraders and beyond-rule-of-five molecules
- High levels of competence in all aspects of modern synthetic chemistry, including single compound synthesis, small parallel arrays, purification methods and analytical characterization
- Significant experience and successful implementation of independent synthetic route design and problem solving
- Familiarity with a variety of biochemical, biophysical, and cellular assays and ability to interpret data derived from such assays
- Understanding of correlations between compound structure, properties, and ADME and ability to optimize multiple parameters
- Proven ability to work well with others in a dynamic and highly collaborative environment
- Excellent communication skills are required, particularly the ability to effectively present work and ideas and contribute to team discussions.
Benefits
Foghorn Therapeutics is pleased to provide you and your family with a comprehensive suite of benefits, including:
- Highly competitive and inclusive medical, dental and vision coverage options
- BCBS PPO and PPO HSA plans
- BCBS Dental Plan
- EyeMed Vision Plan
- FSA and HSA for medical expenses and dependent care expenses
- Free premium access to fitness, nutrition, and mindfulness classes
- Unlimited paid time off policy
- Discretionary winter shut down
- Generous Paid Leave offerings, including 12 weeks of 100% paid parental leave
- Paid Life, LTD and STD insurance coverages, as well as voluntary benefit options
- Free parking or subsidized commuter passes
- Foghorn Therapeutics is a smoke-free, alcohol-free and drug-free work environment.
Foghorn is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law. Foghorn Therapeutics will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. - Health Care Plan (Medical, Dental & Vision)
- Retirement Plan (401k with the company match)
- Life Insurance (Basic, Voluntary & AD&D)
- Unlimited Paid Time Off Policy
- Family Leave (12 weeks for primary caregiver/ birthing parent, 3 weeks for non-primary caregiver)
- Short Term & Long-Term Disability
- Training & Development
- Work From Home
- Free Snacks and Company Lunches on Wednesdays
- Wellness Resources
- Stock Option Plan
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