Senior Research Associate II/Principal Research Associate, Non-Clinical - Research Analytical Discovery

Location

Somerville, MA | United States

Job description

Why Join Us?

Be a hero for our rare disease patients

At Ultragenyx, we fundamentally believe that taking real impactful action to care for the needs of patients and our people is always the right thing to do. To achieve this goal, our vision is to lead the future of rare disease medicine. For us, this means going where other biopharma companies won’t go – challenging the status quo and creating a new model that advances our field so more patients and caregivers can benefit from life-changing treatments. We do this by following the science, applying a novel rapid development approach, making innovative medicines at fair and reasonable prices, and creating a collaborative ecosystem to reach patients in ways that are most meaningful for them. 

Our commitment and care for patients extends to our people, so culture is an essential cornerstone for Ultragenyx. We remain continuously focused on creating a supportive and inclusive environment of profound learning and growth – so employees can thrive in all areas of their lives, in and outside of work. Ultimately, we want to be an organization where we would be proud for our family, friends and children to work.

If you want to have a meaningful impact, do the best work of your career, and grow a lot, both professionally and personally, come join our team.

Position Summary:

ultraimpact – Make a difference for those who need it most

Ultragenyx has multiple Gene Therapy programs in development in the rare and ultrarare disease space, and a robust pipeline. We are building a state of the art GMP manufacturing facility in Bedford, MA. Join our team!

We will assess your level based on your experience before moving forward with full panel interviews.

The candidate will support advancement of innovative AAV-based therapeutics through development and execution of a variety of research methods including molecular and biochemical techniques, mammalian cell culture, and cell-based assays.

Work Model:

Core Lab & Ops: This role typically requires that the majority of the work be conducted on-site and thus will be subject to certain on-site safety protocols during the pandemic.

Responsibilities:

• Independently develop, qualify and/or execute analytical methods to measure and monitor key quality attributes for AAV therapeutic materials.
• Design, develop, and/or execute cell-based and molecular analytical test methods to support characterization and development of AAV pipeline candidates, and further understanding of mechanism of action of potential therapeutic products.
• Work independently and proactively to optimize and troubleshoot analytical assays.
• Evaluate and implement new analytical instrumentation and new technologies.
• Mentor junior staff in execution of cell-based and molecular analytical test methods to support AAV manufacturing platform development.
• Communicate results and research progress during team and departmental meetings, including to senior leadership, as well as participate in scientific conferences.
• Prepare, write, analyze, review, and present technical data and reports.
• Work as part of a cross-functional team to drive innovation in a scientifically stimulating, patient-focused research environment.

Requirements:

• SRA II: MS in Cell Biology, Molecular Biology, Microbiology, Biochemistry or a related discipline with 4+ years relevant experience, or BS with 6+ years relevant experience.
• PRAI: MS in Cell Biology, Molecular Biology, Microbiology, Biochemistry or a related discipline with 6+ years relevant experience, or BS with 8+ years relevant experience.
• Expertise in qPCR, ddPCR, gel electrophoresis methods is required.
• Proficiency with mammalian cell culture, cell- or plate-based assays is required.
• Strong knowledge of molecular biology, immunoassays, protein biochemistry, or biophysical characterization is a must.
• Expertise in DNA/RNA extractions and gene expression analysis is preferred.
• Experience with CE-SDS, MSD ELISA, and AUC is preferred.
• Experience with AAV or other viral vectors is preferred.
• Ability to work in a fast-paced, start-up environment.
• Strong collaboration, team-working skills, and communication skills.
• Self-driven and detail-oriented with excellent problem-solving ability. #LI-CS1 #LI-Onsite

Full Time employees across the globe enjoy a range of benefits, including, but not limited to:

·         Generous vacation time and public holidays observed by the company

·         Volunteer days

·         Long term incentive and Employee stock purchase plans or equivalent offerings

·         Employee wellbeing benefits

·         Fitness reimbursement

·         Tuition sponsoring

·         Professional development plans

* Benefits vary by region and country

Ultragenyx Pharmaceutical is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital and veteran status, and any other status or classification protected by applicable federal, state, and/or local laws. Reasonable accommodation will be provided for all protected statuses or classifications protected by applicable law, including individuals with disabilities, disabled veterans, for pregnancy, childbirth, and related medical conditions, and based on sincerely held religious beliefs. Applicants can request an accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application, or in any part of the recruitment process, you may contact Talent Acquisition by emailing us at [email protected].

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Note to External Recruiters: All candidate activity and open positions are managed strictly through our Human Resources Department. Our Human Resources Department kindly requests that recruiters not contact employees/hiring managers directly in an attempt to solicit business and present candidates. Please note that failure to comply with this request will be a factor in determining a professional relationship with our organization. Submission of unsolicited resumes prior to an agreement set in place between the Human Resources Department and the recruiting agency will not create any implied obligation.  Inquiries on developing a recruiting relationship with us, may be directed to: [email protected].

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