Principal Assay Scientist, Protein Engineering
Location
Abingdon, Oxfordshire | United Kingdom
Job description
Job Details: Principal Assay Scientist, Protein Engineering
Full details of the job.
Vacancy Name
Vacancy No
Vacancy No VN249
Employment Type
Employment Type Permanent
Location of role
Location of role Abingdon
About the Company
About the Company Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry’s most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions.
Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases.
We strive to create a diverse and inclusive workplace, while seeking talented individuals to work with us across the many functions that will allow us to deliver new medicines to transform the lives of patients. You will work with outstanding people who together pioneer the research, development and commercialization of bi-specific TCR therapies. We aim to create an environment where individual contributions and initiatives can be maximized, while fostering a culture of collaboration, based on respect and integrity. We want each individual employee to own their career, as part of high-performing teams, and in the context of on-the-job and formal continuous development and training, as well as constructive feedback. We always strive to identify ways to improve what we do and how we do it, by asking questions, voicing opinions, exploring various approaches and staying connected with healthcare professionals, patients, academia and other key partners.
Key Responsibilities
Key Responsibilities MAIN PURPOSE OF JOB
We are seeking a highly motivated principal assay scientist who will have key responsibilities for identification and development of state-of-the-art assays and high-throughput screens that will enable the discovery of transformative TCR therapeutics. In addition to leading projects evaluating novel and cutting-edge assay technologies, this lab-based role also involves development, optimisation, and validation of new biochemical/cell-based assays from scratch and liaising with automation expertise to establish high-throughput innovative biologics screens that benefit drug discovery.
KEY RESPONSIBILITIES
• Identify innovative assay technologies that will benefit biologic discovery processes
• Lead innovative assay development projects that advance immunotherapy drug discovery workflows aligned with the company’s strategic priorities
• Independently identify, design, develop, and validate novel and state of the art biochemical and cell- based assays in 96/384 plate based or flow cytometry format for discovery of novel immunotherapeutics
• Analyse, interpret and effectively communicate plans and findings at departmental, project, and leadership team meetings, providing go/no go recommendations
• Contribute to defining assay capabilities and strategy for discovery for the next generation of immunotherapeutic molecules
• Liaise with automation expertise to contribute to defining high-throughput assay strategy and solutions for biologics screening
• Liaise with relevant stakeholders across the organisation
• Maintain a good understanding of state-of-the-art assay and high-throughput screening applications for biologics drug discovery across the industry
• Troubleshoot and identify creative, relevant solutions for complex assay and screening challenges
• Lead peer reviewed publications and contributions to patents
• Present at international conferences
• Lead and contribute to internal and external collaborations
• Provide technical training to team members where required
• Ensure own work, and work of peers, follow Good Laboratory Practice, and adhere to Immunocore health and safety policies
EXPERIENCE AND KNOWLEDGE
Essential
• Significant experience in 96/384 well biochemical and cell assay development, validation, and analysis
• Experience in drug discovery
• Experience in flow cytometry
• Experience in leading a team or project(s) and successfully delivering objectives to time
• Familiar with the latest advances in the field of assays and high-throughput screening and their potential application
• Track record of identifying, evaluating, and making recommendations on new technologies to pursue
• Experience in implementing innovative solutions that benefit processes
• Track record of solving scientific problems creatively
• Track record of collaborating and contributing as a project team member
• Track record of building internal and external networks
• Demonstrates strong communication skills with the with the ability to effectively engage with stakeholders of various levels of seniority
• Track record of effective decision making
Desirable
• Experience/knowledge of biologics discovery
• Experienced in high-throughput biologics screening and use of automation
• Experience in programming automation
• Experience in coding analyses scripts for managing large datasets
KEY BEHAVIOURAL ATTRIBUTES
• Attention to quality
• Strong organisation skills with ability to plan, prioritise and coordinate work with others
• Strong team player with ability to actively listen and work productively with other team members in a matrix environment
• Ability to communicate clearly to relevant audiences
• Proactively builds collaborative relationships and fosters innovative thinking
• Ability to think ahead and demonstrate flexibility in response to evolving needs of drug discovery
EDUCATION & QUALIFICATIONS
Degree in biological sciences or a relevant scientific discipline #J-18808-Ljbffr
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