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Research Scientist


Location

Norwich, Norfolk | United Kingdom


Job description

Main Purpose of the Job

To create and contribute to the creation of knowledge by undertaking a specified range of  activities within an established research programme and/or specific research project.

This post is focused on understanding the microbiota of HR+ breast cancer (both beneficial and pathogenic genera) using a variety of samples (clinical cohorts, in vitro, and animal models). A combination of wet and dry approaches are required including microbial genomics, shotgun metagenomics, 16S rRNA amplicon profiling, plus in-depth data analysis and visualisation, culturing, molecular microbiology, in vitro cell line work and in vivo studies will used to integrate microbe-microbe and microbe-host responses.

Key Relationships

Line managers (Robinson and Hall)
Other members of the Robinson and Hall labs
Other stakeholders on the NRP
Communications and Governance at Breast Cancer Now

Main Activities & Responsibilities

Perform in vivo colonisation/tumour studies and associated histological and host response assays and analyses. Utilise in vitro models to probe microbe-host responses

Profile pre-clinical, clinical and animal microbiota profiles using a variety of cutting-edge computational approaches

Isolate and perform mechanistic studies in key cancer patient microbial taxa with a focus on Bifidobacterium.

Carry out in-depth genomic analyses of WGS and MAG data

Develop research objectives and proposals for own or joint research, with assistance of a mentor if required

Contribute to developing new models, techniques and methods

Contribute to enterprise, business development and/or public engagement activities of manifest benefit to the Institute and the University, often under supervision of a project leader

Collect research data; this may be through a variety of research methods, such as scientific experimentation, literature reviews, and research interviews
Present research outputs, including drafting academic publications or parts thereof, for example at seminars and as posters
Provide guidance, as required, to support staff and any students who may be assisting with the research

As agreed with line manager, any other duties commensurate with the nature of the role.

Education & Qualifications

Requirement
Importance
PhD or equivalent qualification relevant to research area
Essential
Robust publication record
Essential

Specialist Knowledge & Skills

Requirement
Importance
High level analytical capability
Essential
Fluency in relevant models, techniques or methods and ability to contribute to developing new ones
Essential
Experience/knowledge of Breast Cancer Immunology
Desirable
Ability to assess resource requirements and use resources effectively
Desirable

Relevant Experience

Requirement
Importance
Knowledge and experience of performing in vitro and in vivo studies with key bacterial taxa (including RNASeq data and histology)
Essential
Experience in bioinformatic analyses of microbiota samples
Essential
Extensive experience of microbial genomics and microbiota profiling and analysis approaches from a variety of sample types
Essential
Experience of working in a laboratory environment
Essential

Management and Leadership

Requirement
Importance
Understanding of and ability to contribute to broader management/administration processes
Desirable
Contribute to the planning and organising of the research programme and/or specific research project
Desirable
Ability to coordinate and manage multiple internal and external projects including presentation to external stakeholders
Desirable
Co-ordinate own work with others to avoid conflict or duplication of effort
Desirable

Interpersonal & Communication Skills

Requirement
Importance
Ability to collaborate with internal and external stakeholders
Essential
Demonstrated ability to work independently, using initiative and applying problem solving skills
Essential
Ability to communicate complex information clearly
Essential
Good interpersonal skills, with the ability to work well as part of a team
Essential
Excellent communication skills, both written and oral, including the ability to present complex information with clarity
Essential

Additional Requirements

Requirement
Importance
Able to present a positive image of self and the Institute, promoting both the international reputation and public engagement aims of the Institute
Essential
Willingness to embrace the expected values and behaviours of all staff at the Institute, ensuring it is a great place to work
Essential
Promotes equality and values diversity
Essential
Willingness to work outside standard working hours when required
Essential
Attention to detail
Essential
Previous/current PIL holder
Desirable


Job tags



Salary

£35.3k - £43.75k per annum

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