Location
Norwich, Norfolk | United Kingdom
Job description
Main Purpose of the Job
To study the role of RNA structure in the post-transcriptional regulation of gene expression in response to stress, mainly temperature. The successful candidate will join a team at JIC working on multiple levels of experiments: genome-wide in vivo RNA structure analysis targeted individual RNA functional motifs' characterisation and corresponding bioinformatics analysis.
Key Relationships
The successful candidate will primarily interact with other researchers including biologists, chemists and computer scientists in the Ding Lab. They will also have regular interactions with the lab collaborators around the world. They will also interact with the other researchers across the Norwich Research Park.
Main Activities & Responsibilities
- Percentage
- Deep sequencing library construction and basic data analysis
- 50
- in vivo RNA structure mapping
- 20
- Biological function characterisation of individual RNA thermometer
- 15
- Presentation of results as papers and seminars, participation in discussion with lab collaborators, attending meetings and seminars, outreach
- 10
- Develop new methods for studying RNA structure
- 5
- As agreed with the line manager, any other duties commensurate with the nature of the post, for example, contributing to the work of Institute committees
Education & Qualifications
- Requirement
- Importance
- Understanding of deep sequencing and RNA structure profiling technologies
- Essential
- PhD in Biology or Chemistry or Bioinformatics
- Essential
Specialist Knowledge & Skills
- Requirement
- Importance
- Deep sequencing library construction and analysis
- Essential
- Molecular biology
- Essential
- RNA biology
- Essential
- Nucleic acid chemistry
- Essential
- Regulation of gene expression
- Essential
- RNA structure profiling background
- Essential
Relevant Experience
- Requirement
- Importance
- Previous experience in genome-wide study
- Essential
- Previous experience of plant transformation
- Essential
- Previous experience of working on regulation of gene expression
- Essential
- Extensive experience in transcriptome study
- Desirable
Interpersonal & Communication Skills
- Requirement
- Importance
- Evidence of intellectual independence, rigour and creativity
- Essential
- Demonstrated ability to work independently, using initiative and applying problem solving skills
- Essential
- Experience of oral presentation to scientific audiences
- Essential
- Good verbal and written communication skills
- Essential
- Good interpersonal skills with the ability to work well as part of a team and lead a team
- Essential
Additional Requirements
- Requirement
- Importance
- Attention to detail
- Essential
- Willingness to embrace the expected values and behaviours of all staff at the Institute, ensuring it is a great place to work
- Essential
- Able to present a positive image of self and the Institute, promoting both the international reputation and public engagement aims of the Institute
- Essential
- Willingness to work outside standard working hours when required
- Essential
- Promotes equality and values diversity
- Essential
Job tags
Salary
£35.3k - £43.75k per annum
