Location
Abingdon, Oxfordshire | United Kingdom
Job description
About the Company Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry’s most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions.
Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases.
We strive to create a diverse and inclusive workplace, while seeking talented individuals to work with us across the many functions that will allow us to deliver new medicines to transform the lives of patients. You will work with outstanding people who together pioneer the research, development and commercialization of bi-specific TCR therapies. We aim to create an environment where individual contributions and initiatives can be maximized, while fostering a culture of collaboration, based on respect and integrity. We want each individual employee to own their career, as part of high-performing teams, and in the context of on-the-job and formal continuous development and training, as well as constructive feedback. We always strive to identify ways to improve what we do and how we do it, by asking questions, voicing opinions, exploring various approaches and staying connected with healthcare professionals, patients, academia and other key partners.
Key Responsibilities
Key Responsibilities MAIN PURPOSE OF JOB
To conduct and design experimental investigations to support a low dose parenteral bio-pharmaceutical in the development and management of integrated formulation strategies supporting Immunocore’s bio-pharmaceutical platforms. Formulations designed to meet different routes of delivery such as Sub-cutaneous. In-depth knowledge of lyophilisation of biologics. The formulation role will cover early stressing studies, formulation excipient screening, CMC process support, drug substance and drug product through to compatibility with final patient delivery systems. Support and direct IUS studies and progress the clinical programmes. Support and respond to main stake holders for example Clinical and Regulatory teams in the delivery of the clinical strategies.
To work in close collaboration with the other Formulation scientists, CMC teams and related functions to input into the formulation related sections for regulatory filings, development reports and other development related documents. Run new formulation methodologies supporting lyophilised presentations
KEY RESPONSIBILITIES – ALL SCIENTISTS
• Conducting experiments, observing, interpreting and responding to results.
• Maintaining and increasing technical knowledge in relevant fields through self-study, observation, attending relevant conferences and training courses.
• Maintaining accurate records of all work by completing laboratory notebooks on time, following Company procedures
• Ensuring that laboratory equipment is operated in accordance with safety and risk guidelines; acting promptly to report any faults or problems to the relevant member of staff.
• Operating in accordance with the Company’s Health and Safety policies, especially within a laboratory environment.
SPECIFIC RESPONSIBILITIES
• Experiments: independently testing and, increasingly, leading lines of investigation. Proposing new experiments based on emerging data and other related information. Providing support on technical aspects to others. Specifically:
a. To conduct and design experiments to establish lyophilised & liquid formulations for TCR platform API and IMP
b. Lead and direct pre-formulation, cycle 1,2 and 3 activities
c. Understand and develop sub-cutaneous formulations
d. Working with PFS for sub-cutaneous administration
e. Good understanding of lyophilised formulations
f. Represent formulation in CMC teams
g. Investigate compatibility of drug product through delivery devices for patient administration
h. Investigations in novel drug delivery formats
i. Perform testing and develop test methods to support stability and formulation studies.
j. Carry out and optimise production of recombinant protein supportive reagents, including conjugations
k. Communicate key findings to managers and scientists in other groups
l. Review/sign-off of routine assays.
m. Writing of SOPs.
n. Contributing to regulatory documentation
o. Participation in laboratory maintenance.
p. Support IUS studies.
q. Support clinical compatibility studies.
r. Support investigations into IUS clinical site excursion event impacts.
s. Identify new external scientific technology and collaborations.
t. Introduce new science into the group.
• Priorities: establishing priorities for own work and team-based projects; making decisions on prioritisation based on the overall goals of the team, department and project, using direct evidence and personal experience as guidance.
• Technical Knowledge: sharing knowledge with the wider team and, across departments representing the department both internally. May also act as a mentor or manager to other colleagues, especially new hires, sharing scientific and company knowledge. Increasingly providing analysis of new techniques and theories from outside the Company to advance the way the company works; sharing these with leaders across the Company.
• Laboratory records: ensuring that all records and information are up to date, on time and recorded to the correct standard. Supporting and encouraging others to achieve this.
• Laboratory equipment: providing technical guidance to others within the team on how to use equipment most effectively; making recommendations regarding acquisition of new pieces of equipment.
• Health & Safety: championing and helping others to understand H&S within the company, providing ad-hoc training as required.
• Reporting: communicating and presenting research findings at meetings with colleagues, senior management and partners..
OTHER
• May also act as a mentor or manager to other colleagues, especially new hires
EXPERIENCE AND KNOWLEDGE
Essential
• Background in recombinant protein or antibody formulation, analytical development or protein characterisation, with proven industry experience and exposure to formulation strategies.
• Strong experience of developing sub-cutaneous formulations
• Experience in design of formulation studies, including the utilisation of design of experiments principles.
• Strong expertise in electrophoretic or chromatographic assays and general biochemical lab techniques.
• Experience in developing lyophilised formulation
Desirable
• Experience of process development for production of biologics and conjugation of biomolecules
• Familiar with biopharmaceutical stability study principles
• Familiarity with novel drug delivery formats
• proactive in ensuring high quality of their work and seeking additional responsibilities to help meeting the goals of the team
• Presented detailed scientific findings and papers to internal audiences
EDUCATION & QUALIFICATIONS
• Essential: MSc. In bio-manufacturing, protein engineering, biochemistry, molecular biology or related discipline
• Desirable: PhD in related discipline #J-18808-Ljbffr
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