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Senior Scientist I


Immunocore


Location

Abingdon, Oxfordshire | United Kingdom


Job description

About the Company Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry’s most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions.

Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases.

We strive to create a diverse and inclusive workplace, while seeking talented individuals to work with us across the many functions that will allow us to deliver new medicines to transform the lives of patients. You will work with outstanding people who together pioneer the research, development and commercialization of bi-specific TCR therapies. We aim to create an environment where individual contributions and initiatives can be maximized, while fostering a culture of collaboration, based on respect and integrity. We want each individual employee to own their career, as part of high-performing teams, and in the context of on-the-job and formal continuous development and training, as well as constructive feedback. We always strive to identify ways to improve what we do and how we do it, by asking questions, voicing opinions, exploring various approaches and staying connected with healthcare professionals, patients, academia and other key partners.

Key Responsibilities

Key Responsibilities MAIN PURPOSE OF JOB

We are seeking a highly motivated senior scientist who will have key responsibilities for developing and expanding high throughput developability assay capabilities for the discovery of transformative TCR medicines. In addition to identifying and building innovative and state state-of-the-art assays to assess biophysical and functional properties of panels of potential candidate TCR therapeutics, the role will involve liaising with Development, Drug Discovery and automation scientists to streamline drug discovery.

KEY RESPONSIBILITIES

• Independently identify, design, develop, and validate state of the art assays for assessment of biophysical and functional properties of T cell engager molecules.
• Liaise with drug discovery and development colleagues to streamline biologics developability assessment for candidate selection
• Liaise with automation expert when needed to build high-throughput assay capability
• Analyse, interpret and effectively communicate experimental results, recommendations, and plans to project teams
• Maintain a good understanding of state-of-the-art and emerging biologics drug formats and the assays used to assess their biophysical properties
• Contribute to identifying, evaluating, building, and applying innovative assays and streamlining drug discovery processes
• Troubleshoot and identify resourceful, relevant solutions for complex scientific challenges
• Contribute to peer reviewed publications, patents and international conferences
• Contribute to internal and external collaborations
• Provide technical training to team members
• Ensure own work, and work of peers, follow Good Laboratory Practice, and adhere to Immunocore health and safety policies

PERSON SPECIFICATION

EXPERIENCE AND KNOWLEDGE

Essential
• Experienced in evaluating biologics developability criteria such as sequence liabilities, biophysical and functional properties of molecules
• Experience in protein structural analyses and application for developability
• Experience in performing standard molecular biology techniques
• Experience in performing biologics assays
• Experience in TCR drug discovery
• Track record of solving scientific problems creatively
• Track record of collaborating and contributing as a project team member
• Effective communication of scientific concepts and findings

Desirable
• Experienced in use of automation e.g., liquid handlers
• Experienced in use of functional cell assays for biologics
• Track record of evaluating innovative solutions to improve processes
• Experience in phage display techniques

KEY BEHAVIOURAL ATTRIBUTES
• Attention to detail and quality
• Strong organisation skills with ability to plan, prioritise and coordinate work with others
• Strong team player with ability to actively listen and work productively with other team members in a matrix environment
• Ability to communicate clearly to relevant audiences
• Demonstrates innovative thinking

EDUCATION & QUALIFICATIONS

PhD with 2 or more years’ relevant experience or a degree in biological sciences with relevant lab- based experience. #J-18808-Ljbffr


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