Principal Protein Scientist

Location

Central London | United Kingdom

Job description

Position: Principal Protein Scientist

Our client is looking for a protein scientist with a background in Immunology, Protein Biochemistry and Molecular Biology. You will play a pivotal role in establishing in-house capabilities for TCR library building and advancing our preclinical pipeline of bispecific T cell engagers. You will be instrumental in designing, conducting, and evaluating experiments while ensuring scientific excellence within our Protein Biochemistry function.

Key Responsibilities:

• Establishing in-house TCR library building capabilities for engineering TCR-directed, bispecific T-cell engagers.
• Setting up in-vitro display platforms (mammalian and yeast) for identification.
• Conducting selections of the best binders using in-vitro display platforms. 
• Designing, conducting, and evaluating experiments to advance our preclinical pipeline. 
• Actively participating in cross-functional team meetings, discussing data, seeking advice, and providing expertise to drive future strategies.
• Maintaining scientific excellence within the Protein Biochemistry function.
• Contributing to a vibrant and innovative working environment where improvements and new ideas are adopted and shared among teams.

Skills and Qualifications:

• Ph.D. or equivalent scientific experience in Immunology, Molecular Biology, Biochemistry, or a related discipline.
• Hands-on experience in molecular biology techniques. 
• Technical expertise in in-vitro display, preferably including mammalian or yeast display or phage display.
• Experience with antibody or TCR library building is highly desirable.
• Strong communication skills and a collaborative mindset to work effectively in a team-oriented environment.

Additional Attributes:

• Strong analytical skills with a commitment to scientific integrity and innovation.
• Ability to diagnose and overcome technical challenges effectively.
• Prioritization skills to manage multiple projects and meet deadlines in a fast-paced environment.
• Flexibility to adapt within an interdisciplinary team setup.
• Experience in bioorthogonal chemistry, bioconjugation, lipid nanoparticle formulation, cell and immunological assays (e.g., flow cytometry, ELISA), NGS analysis pipeline, and SOP documentation is preferred.

What We Offer:

• Competitive salary package.
• Generous leave policy, including holidays and a birthday holiday.
• Access to a fully-equipped private lab.
• Flexible work arrangements, including work-from-home options.
• Supportive, cross-disciplinary team fostering a highly collaborative work environment.

Job tags

Salary