IGBMC
Location
Illkirch Graffenstaden, Bas Rhin | France
Job description
New postdoc and doctoral positions available in the laboratory of Romeo Ricci at the IGBMC in Strasbourg, France (www.igbmc.fr/en; https://www.igbmc.fr/en/recherche/teams/signal-transduction-in-metabolism-and-inflammation). Our institute is a leading research institution in Europe currently hosting 46 teams with researchers from all over the world. It is a facility-driven institute with state-of-the-art equipment and core expertise covering all experimental techniques of the project. Strasbourg is in the beautiful, wine-growing area of Alsace, in proximity of Germany and Switzerland.
Référence
P-Doc & Doctorat Eq. R. RICCI
Type de contrat
POST-DOC
Date de publication
29/01/2024
The inflammasome is an intracellular multiprotein complex that senses sterile tissue damage and infectious agents to initiate innate immune responses. Distinct inflammasomes containing specific sensing molecules exist. The NLRP3 inflammasome is unique as it detects a broad range of cellular stress signals but a primary and converging sensing mechanism initiating inflammasome assembly remains ill-defined. We found that NLRP3 binds altered endomembranes because of disruption of inter-organelle contact sites in response to danger signals. However, little is known about this fundamentally new mechanism of pattern recognition linking organelle spatial organization and innate immunity. The organelle-generated signals sensed by NLRP3 and the mechanisms underlying membrane recruitment and activation of the inflammasome remain largely unexplored and thus will be subject of this proposal. The major limit hampering their identification is the difficulty to disentangle the complex cell response to the variety of stimuli leading to NLRP3 activation. We aim to push this limit through an unprecedented combination of approaches ranging from in vitro reconstitution studies with isolated organelles and artificial liposomes and proteo-lipidomics, to cryo-FIB and cryo-ET imaging, molecular modelling, and in vivo testing of the physiological relevance of in vitro findings. This project will lay the foundation for how altered endomembranes serve as danger-associated molecular patterns to trigger innate immune responses.
Applications including cover letter, detailed CV, copies of certificates, and contact information of two referees, should be sent latest 1st of Mai 2024 as a single pdf file (no more than 10 MB) via email to: [email protected].
Associé à :
Équipe(s) : La signalisation cellulaire de stress dans le métabolisme et l'inflammation
Job tags
Salary
