Institute for Research in Biomedicine Barcelona
Location
Barcelona | Spain
Job description
A) RESEARCH LABORATORIES · Barcelona
Postdoctoral Fellow in Liver Disease and Cancer Research (ref. PD/24/01) Created in 2005 by the Generalitat de Catalunya (Government of Catalonia) and the University of Barcelona, IRB Barcelona is a Severo Ochoa Centre of Excellence--a seal that was awarded in 2011. The institute is devoted to conducting research of excellence in biomedicine and to transferring results to clinical practice, thus improving people’s quality of life, while simultaneously promoting the training of outstanding researchers, technology transfer, and public communication of science. Its 29 laboratories and seven core facilities address basic questions in biology and are orientated to diseases such as cancer, metastasis, Alzheimer’s, diabetes, and rare conditions. IRB Barcelona is an international centre that hosts 500 members and 45 nationalities. It is located in the Barcelona Science Park. IRB Barcelona forms part of the Barcelona Institute of Science and Technology (BIST) and the "Xarxa de Centres de Recerca de Catalunya" (CERCA). IRB Barcelona is seeking a Postdoctoral Fellow to join the laboratory of to participate in a cutting-edge research project funded by the AECC (Spanish Association Against Cancer). The project will be developed in collaboration with the laboratories of Mercedes Fernandez ( IDIBAPS , Barcelona) and Salvador Aznar-Benitah (IRB Barcelona), with external support from Jonel Trebicka (Münster University, Germany). The project focuses on understanding the intricate mechanisms leading to the loss of the liver’s stress response mechanism following dietary fat consumption. Our research team has identified key signaling factors in this process and is actively working on developing therapeutic strategies to modulate their activity. The goal is to restore the liver’s stress-coping abilities, eliminate epigenetic memory associated with parental fat consumption, and develop innovative therapies for liver cancer in an aging population with high dietary fat intake. The project focuses on understanding the intricate mechanisms leading to the loss of the liver’s stress response mechanism following dietary fat consumption. Our research team has identified key signaling factors in this process and is actively working on developing therapeutic strategies to modulate their activity. The goal is to restore the liver’s stress-coping abilities, eliminate epigenetic memory associated with parental fat consumption, and develop innovative therapies for liver cancer in an aging population with high dietary fat intake. This is a unique opportunity to contribute to groundbreaking research in a vibrant and collaborative scientific community. We are seeking a dynamic and accomplished individual to contribute to translational research at the intersection of liver disease and cancer. Join us in making a meaningful impact on liver disease and cancer research. Immediate incorporation is possible/desirable. Relevant publications for the project 1. Bava, FA., Eliscovich, C., Ferreira, PG., Miñana, B., Ben-Dov, C., Guigó, R., Valcárcel, J. and Méndez, R. "CPEB1 coordinates alternative 3’UTR formation with translational regulation". Nature, 495(7439):121-125 (2013). 2. Calderone V, Gallego J, Fernandez-Miranda G, Garcia-Pras E, Maillo C, Berzigotti A, Mejias M, Bava FA, Navarro P, Bosch J, Fernandez M*, Mendez R*. "Sequential functions of CPEB1 and CPEB4 regulate VEGF expression and angiogenesis in chronic liver disease". Gastroenterology. 150(4): 982-997.e30 (2016) 3. Carlos Maillo, Judit Martín, Maribel Hernández, David Sebastián, Mar García-Rocha, Antonio Zorzano, Mercedes Fernandez*, Raúl Méndez*. "Circadian and UPR-dependent control of CPEB4 mediates a translational response to counteract hepatic steatosis under ER stress" Nature Cell Biology. 19, 94-105 (2017). 4. Sato S, Solanas G, Peixoto FO, Bee L, Symeonidi A, Schmidt MS, Brenner C, Masri S, Benitah SA*, Sassone-Corsi P* Circadian Reprogramming in the Liver Identifies Metabolic Pathways of Aging. Cell. 2017 Aug 10;170(4):664-677. 5. Koronowski KB, Kinouchi K, Welz PS, Smith JG, Zinna VM, Shi J, Samad M, Chen S, Magnan CN, Kinchen JM, Li W, Baldi P, Benitah SA*, Sassone-Corsi P*.Defining the Independence of the Liver Circadian Clock. Cell. 2019 May 30;177(6):1448-1462 6. Greco CM, Koronowski KB, Smith JG, Shi J, Kunderfranco P, Carriero R, Chen S, Samad M, Welz PS, Zinna VM, Mortimer T, Chun SK, Shimaji K, Sato T, Petrus P, Kumar A, Vaca-Dempere M, Deryagin O, Van C, Kuhn JMM, Lutter D, Seldin MM, Masri S, Li W, Baldi P, Dyar KA, Muñoz-Cánoves P, Benitah SA*, Sassone-Corsi P* Integration of feeding behavior by the liver circadian clock reveals network dependency of metabolic rhythms. Sci Adv. 2021 Sep 24;7(39) 7. Marcos Fernández-Alfara, Annarita Sibilio, Judit Martin, Elsa Tusquets Uxó, Marina Malumbres, Victor Alcalde, Veronica Chanes, Adrià Cañellas, Sergio Palomo-Ponce, Eduard Batlle and Raúl Méndez."Antitumor T cell function requires CPEB4-mediated adaptation to chronic endoplasmic reticulum stress" EMBO Journal e111494 (2023) 8. Smith JG, Koronowski KB, Mortimer T, Sato T, Greco CM, Petrus P, Verlande A, Chen S, Samad M, Deyneka E, Mathur L, Blazev R, Molendijk J, Kumar A, Deryagin O, Vaca-Dempere M, Sica V, Liu P, Orlando V, Parker BL, Baldi P, Welz PS, Jang C, Masri S, Benitah SA, Muñoz-Cánoves P, Sassone-Corsi PLiver and muscle circadian clocks cooperate to support glucose tolerance in mice. Cell Rep. 2023 Jun 27;42(6):112588. DUTIES: Conduct in-depth research using last-generation multi-omic analyses, including epigenome, epitranscriptome, translatome, metabolome, etc. Conduct research using genetically modified mouse models of disease and analyze patient samples. Independently design and test biological hypotheses. Collaborate with a multidisciplinary research team, tapping into the expertise of fellow researchers and external collaborators. Contribute to a culture of scientific excellence, efficiency, and teamwork. EXPERIENCE, KNOWLEDGE, SKILLS: Must Have - Required: PhD in a relevant field. Experience in conceptual or technical aspects related to the project. Strong background in liver biology, cancer, or related fields. Demonstrated ability to design and conduct experiments independently. Excellent communication skills and the ability to collaborate effectively. WORKING CONDITIONS & ENTITLEMENTS: Working conditions : Employed in compliance with Spanish legislation and regulations under a full-time contract. Employees receive the benefits of the Spanish Social Security system covering sickness, maternity/paternity leaves and injuries at work. Training and Career: Postdoctoral researchers joining IRB Barcelona gain access to the Institute’s advanced research training and career development opportunities, all within in a competitive international environment. Courses and workshops on themes of particular interest to postdocs are offered regularly by the Institute. Estimated annual gross salary: Salary commensurate with experience and qualifications. International environment: Nearly 90 Postdoctoral researchers (more than a half non-Spanish nationals) are currently working at IRB Barcelona. HOW TO APPLY & SELECTION PROCESS: Applications for the above opening should include Full CV, Motivation Letter and references. Deadline for applications : 01/02/2024 (If no suitable candidate is found, the deadline will be extended) Number of positions available : 1 Selection process: Pre-selection : Will be based on CV, motivation letter & experience. Interviews : Short-listed candidates will be interviewed. Job offer : Will be sent to the successful candidate after the interview. Note: The strengths and weaknesses of the applications will be provided upon request. Join Us Postdoctoral Fellow (ref. PD/24/02) A) RESEARCH LABORATORIES · Barcelona Postdoctoral Fellow for the Inflammation, Tissu... A) RESEARCH LABORATORIES · Barcelona Laboratory Technician (ref. LAB/23/45) A) RESEARCH LABORATORIES · Barcelona A) RESEARCH LABORATORIES · Barcelona Postdoctoral Fellow in Liver Disease and Cancer Research (ref. PD/24/01) Career site Start Jobs Data & privacyIn your application, please refer to myScience.org and reference JobID 2826470 .
Job tags
Salary
