Roche
Location
Penzberg | Germany
Job description
In Roche`s Pharmaceutical Research and Early Development organization (pRED), we make transformative medicines for patients in order to tackle some of the world`s toughest unmet healthcare needs. At pRED, we are united by our mission to transform science into medicines. Together, we create a culture defined by curiosity, responsibility and humility, where our talented people are empowered and inspired to bring forward extraordinary life-changing innovation at speed.
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The position
A key feature of next-generation rAAV-based gene therapies is the targeted expression of transgene in a cell type- or disease state-specific manner. This allows to detarget undesired tissues and cell populations to increase safety and thus expands the therapeutic space of rAAV gene therapies in general.
As a Roche RPF Postdoctoral Fellow (m/f/d) in our Nucleic Acid Based Medicine (NABM) matrix team, you will focus on an exploratory research project related to the development of novel gene regulatory elements, which allow precise regulation of therapeutic transgene expression. To achieve this goal, you will identify, functionally validate and optimize novel genetic elements in alignment to current and further portfolio needs at Roche pRED. This gives you the opportunity to collaborate and connect to different functions internally as well as to external academic partners.
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Main task of this position:
You will utilize state of the art computational tools (in R or Python) to analyze large datasets in order to identify endogenous regulatory DNA sequences
You will establish and perform NGS based high-throughput screening assays to functionally characterize DNA sequences
You will employ machine learning approaches to build fully synthetic regulatory elements in close collaboration with our computational department
You will manage and organize the experimental workstream between different wet and dry lab teams.
This position is sponsored by the Roche Postdoctoral Fellowship Programme. The RPF Programme has the ambition to build and maintain the Scientific Leadership of the future and to provide leading Roche scientists with the opportunity to collaborate with talented postdoctoral researchers, and leading academic research groups, from around the world. The duration of the RPF project is initially set for two years, with the possibility of extension for a third year. You will be based in Penzberg within the greater Munich area (Germany).
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Essential skills and expertise:
Experience in design and cloning of large DNA barcoded libraries
Understanding of transcriptional and translational gene regulation
PhD in molecular biology
Self-organized, autodidactic and creative mindset to establish novel high-throughput screening approaches
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Preferred skills and qualifications:
Generation of costume NGS sequencing libraries
Basic computational experience in either R or Python
Experience in generating and working with different multiomic or epigenetic datasets
Fluent communication skills with both computational and biological scientists in English
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We anticipate the start date of this fellowship to be mid-2024, by which point you should have successfully handed in your PhD thesis or no later than 5 years after the PhD. To be considered, please send a CV, at least one reference contact as well as a short motivation letter (maximum half a page) that highlights your key research experience that makes you a good fit for this position.
We look forward receiving your application!
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Our commitment
Roche commits to recognizing talent and aptitude. We prioritize encouraging and supporting our employees in their personal journeys by providing a safe, creative space to help them reflect, make decisions and grow in their career. We are confident that we find the most innovative solutions by gaining different perspectives, asking and answering hard questions, and challenging the status quo. Roche embraces diversity and equal opportunity in a serious yet enthusiastic way; we are devoted to building a team that represents a range of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.
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Your contact to us! With people. For people.
Do you need more support?
Our Talent Acquisition Team welcomes your questions.
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Who we are
At Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we`ve become one of the world`s leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.
Roche at Penzberg, near Munich, employs more than 7,000 people. The site is one of the largest biotechnology centers in Europe and the only Roche site with research, development and production for both Pharmaceuticals and Diagnostics under one roof. From your beginning with Roche, our motivated team will welcome and support you. Numerous opportunities for personal development, flexible work hours, attractive compensation packages and special family assistance programs are available.
Roche is an Equal Opportunity Employer.
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