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PhD Biochemistry - Neurobiology, Myogenesis, Skeletal Muscle (m/f/d)


Universität Erlangen-Nürnberg


Location

Schwabach | Germany


Job description

Our collegial and friendly research group (Prof. Hashemolhosseini, Chair Prof. Wegner) is interested in molecular physiological and pathophysiological aspects of skeletal muscle biology; in particular also muscular dystrophies, myopathies, myasthenias and muscle tumors (rhabdomyosarcoma).

Selected papers:

- The YAP1/TAZ-TEAD transcriptional network regulates gene expression at neuromuscular junctions in skeletal muscle fibers. Gessler L, Huraskin D, Jian Y, Eiber N, Hu Z, Prószyński TJ, Hashemolhosseini S. Nucleic Acids Res. 2023 Dec 4:gkad1124. doi: 10.1093/nar/gkad1124.

- In Adult Skeletal Muscles, the Co-Receptors of Canonical Wnt Signaling, Lrp5 and Lrp6, Determine the Distribution and Size of Fiber Types, and Structure and Function of Neuromuscular Junctions. Gessler L, Kurtek C, Merholz M, Jian Y, Hashemolhosseini S. Cells. 2022 Dec 8;11(24):3968. doi: 10.3390/cells1124396

- In mammalian skeletal muscle, phosphorylation of TOMM22 by protein kinase CSNK2/CK2 controls mitophagy. Kravic B, Harbauer AB, Romanello V, Simeone L, Vögtle FN, Kaiser T, Straubinger M, Huraskin D, Böttcher M, Cerqua C, Martin ED, Poveda-Huertes D, Buttgereit A, Rabalski AJ, Heuss D, Rudolf R, Friedrich O, Litchfield D, Marber M, Salviati L, Mougiakakos D, Neuhuber W, Sandri M, Meisinger C, Hashemolhosseini S. Autophagy. 2018;14(2):311-335. doi: 10.1080/15548627.2017.1403716. Epub 2018 Feb 1.

- Wnt/β-catenin signaling via Axin2 is required for myogenesis and, together with YAP/Taz and Tead1, active in IIa/IIx muscle fibers. Huraskin D, Eiber N, Reichel M, Zidek LM, Kravic B, Bernkopf D, von Maltzahn J, Behrens J, Hashemolhosseini S. Development. 2016 Sep 1;143(17):3128-42. doi: 10.1242/dev.139907. Aufgaben:
A broad spectrum of molecular and cell biological methods, transgenic mouse models and diagnostic analysis of patient material will be used. Qualifikationsprofil:
We are looking for motivated applicants from the field of biochemistry/biology/chemistry/molecular medicine for a PhD project. Benefits:
We offer a friendly and collegial working atmosphere and a flat hierarchy.
We also help candidates on their further career path after graduation.


Job tags

VollzeitPhD Position


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