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Location

Heidelberg | Germany

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Job description

wanted at the next possible time at Department of General Pharmacology.

The genome editing platform will be established within the Department of General Pharmacology (Prof. Dr. Marc Freichel) and in the context of the Health + Life Science Alliance Heidelberg Mannheim (). The group will have resources for the position of the leader, consumables and technical support. Support will also be provided for acquiring additional third-party funding. The platform will have close connections to existing core facilities and platforms of the Health + Life Science Alliance and its seven institutions, as well as research consortia such as the German Health Centers (DZHK, DKTK, DZL, DZIF) and Collaborative Research Centers (CRCs) at Heidelberg University. Collaboration with these institutions and research consortia is explicitly desired. Additionally, an interest in participating in new collaborative initiatives, including new clusters of excellence, is expected.

The research and tasks of the platform include:

• Development and optimization of genome editing procedures: The group works on developing new technologies and methods for precise genome editing and further advancing existing procedures. This includes techniques such as CRISPR/Cas9, Base Editing, and Prime Editing.

• Establishment of preclinical disease models: By applying genome editing techniques, preclinical disease models are developed in mice and other animal or organoid models. These models allow for investigating the molecular basis of diseases, identifying signaling pathways, and exploring new therapeutic approaches.

• Development of in vitro models: The Junior Research Group also utilizes in vitro models derived from iPS cells. These cell models enable the investigation of disease mechanisms in a controlled environment and the testing of potential therapeutic approaches.

Your Tasks

• You are responsible for further development of technologies in the field of genome engineering
• You will help establish and lead the platform as an information, contact, and service facility for members of the Health + Life Science Alliance
• In your role as the platform leader, you will be responsible for finances and personnel
• In close coordination with the Department of General Pharmacology and in collaboration with Health + Life Science Alliance management your role will involve spearheading the further development of the platform
• You will actively be involved in research questions related to genome editing within the Health + Life Science Alliance Heidelberg Mannheim.
• You will establish collaborative projects with other members of the Health + Life Science Alliance within the framework of funding instruments for research consortia (DZGs, CRCs) at Heidelberg University
• Your expertise will be integrated into future project proposals to acquire further funding for the implementation of genome engineering techniques
• Optionally, you may participate in university self-administration and teaching

Your Profile

• A successfully completed Ph.D. in biosciences, medicine, veterinary medicine, pharmacy, or an equivalent degree is required
• Solid knowledge and extensive experience in the generation and molecular analysis of transgenic model systems in animals, especially in mice, or in iPS cells with the application of genome editing techniques are essential
• Good English language skills and German language skills are desirable
• You demonstrate the ability to work independently and autonomously
• Evidence of leadership experience and experience in supervising final theses is advantageous and will be positively evaluated
• Enthusiasm for an exciting, dynamic, and challenging position in medically oriented

About us

For inquiries, please contact Prof. Dr. Marc Freichel via email or phone: +49 6221-54 86860.

Interested? 

Please submit your application, including the usual documents, via email by March 31st, 2024 to: [email protected]  

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Job tags

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Salary