Medizinische Hochschule Hannover
Location
Lehrte | Germany
Job description
The Institute of Molecular and Cell Physiology, Medical School Hannover is looking for a talented and motivated PhD candidate (m/f/d) with an interest in bioinformatics, biochemistry, cell biology, molecular biology and muscle physiology. We welcome applications from candidates with an MSc-degree in life sciences.
Aufgaben:
Project description:
The relevance of the SUMO (small ubiquitin-like modifier) pathway in muscle physiology is an emerging aspect of biology, which remains poorly understood. Muscle atrophy/cachexia - an end stage muscle wasting disorder associated with cancer and several other diseases- severely perturbs muscle mass and function. Recently, we showed that epigenetic regulatory features of the SUMO pathway are involved in correct organization of the sarcomere, the fundamental structural and functional unit of striated muscle cells. One key question i.e., whether SUMO pathway as a whole is associated with muscle organization and cachexia remained unknown. By employing ChIPseq, RNAseq and proteomic tools, the proposed PhD project aims to investigate further crucial roles of the SUMO isopeptidases in muscle cell organization and cachexia. For more information on the project background, check the following references.
- Khan B, Gand LV, Amrute-Nayak M, and Nayak A * . (2023). Emerging mechanisms of skeletal muscle homeostasis and cachexia: The SUMO perspective. Cells . Feb 17;12 (4):644.
- Amrute-Nayak, M., Gand, LV., Khan, B., Holler T, Kefalakes, E., Kosanke, M., Kraft, T., and Nayak A* . (2022). SENP7 deSUMOylase-governed transcriptional program coordinates sarcomere assembly and is targeted in muscle atrophy. Cell Reports. Nov 22;41(8):111702. (* Corresponding author).
- Amrute-Nayak, M., Pegoli, G., Holler, T., Lopez-Davila, AJ., Lanzuolo, C., and Nayak, A * . (2020). Chemotherapy triggers cachexia by deregulating synergetic function of histone-modifying enzymes. J Cachexia Sarcopenia Muscle . Dec 10. doi: 10.1002/jcsm.12645. (* Corresponding author).
Qualifikationsprofil:
What we are looking for: - We expect excellent academic scores and prior research experience.
- Good knowledge in bioinformatics (R, Galaxy, IPA, etc.) and proteomics data analysis (MaxQuant, Cytoscape) is a strong plus.
- Theoretical and basic practical knowledge in cell and molecular biology and biochemistry.
- Analytical and goal-oriented approach towards project.
- Preparedness to work independently, as well as in a team and take project and lab-related responsibilities.
Benefits:
- A Ph.D. position initially for three years with possibility of extension.
- An exciting project with defined objectives of potential clinical significance.
- An international working atmosphere.
- State-of-the-art research facilities and possibilities of collaborative research including working with human-derived muscle cells/tissue.
- Participation in academic teaching activities.
- Opportunities for further research-related and teaching-related skill development.
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