Universitätsklinikum Ulm
Location
Ulm | Germany
Job description
The University Hospital Ulm and its employees stand for a modern and high quality patient care, excellent university research and medical education focused on the future as well as apprenticeships in attractive professional fields. The requirements for this are qualified and committed employees.
Characterization of NK cell development in a human iPSC-model
In the scope of this project we plan to characterize the commitment of hematopoietic stem progenitor cells to the natural killer (NK) cell lineage in early lymphocyte development. Defined NK cell populations will be studied in NK lymphocytes derived from genetically engineered human induced pluripotent stem cells (iPSCs) in vitro, as well as in peripheral blood obtained from healthy controls and patients suffering from different diseases.
NK cells belong to the innate immune system and play an important role in the viral immune defense and tumor surveillance by mediating cellular cytotoxicity. During their development, which starts in the bone marrow and proceeds in secondary lymphoid organs, NK lymphocytes are shaped by external and endogenous factors that will be investigated in this project.
We offer:
Die Einstellung erfolgt über die Verwaltung des Klinikums im Auftrag des Landes Baden-Württemberg. Personen mit Schwerbehinderung werden bei gleicher Eignung vorranging eingestellt. Das Universitätsklinikum Ulm strebt die Erhöhung des Frauenanteils in den Bereichen an, in denen Sie unterrepräsentiert sind. Entsprechend qualifizierte Frauen werden um ihre Bewerbung gebeten.
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