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Postdoc Biochemistry - Proteomics (m/f/d)


Helmholtz-Zentrum für Umweltforschung GmbH - UFZ


Location

Weißenfels | Germany


Job description

The Helmholtz Centre for Environmental Research (UFZ) with its 1,100 employees has gained an excellent reputation as an international competence centre for environmental sciences. We are part of the largest scientific organisation in Germany, the Helmholtz Association. Our mission: Our research seeks to find a balance between social development and the long-term protection of our natural resources. Postdoc (f/m/x)

The Department of Molecular Toxicology seeks a creative and enthusiastic postdoctoral fellow. The position is placed within the Toxicoproteomics group, led by Emmy-Noether-Group leader Kristin Schubert. In this position, the fellow will investigate molecular mechanisms linking chemical exposure to inflammation and adipose tissue dysfunction. The research fellow will use quantitative proteomics approaches to define molecular changes induced in human immune cells and adipocytes by exposure to environmental chemicals of concern at the bulk and single-cell levels. In addition, a strong focus on the role of posttranslational protein modifications is expected, including functional validations using complementary methods. The position requires a solid background in molecular wet-lab techniques and reliable handling of R. The start of the project will preferably be the 1 st of June 2024.

Place of work:
Leipzig

Working time:
100 %

Contract limitations:
limited contract/2 years

Salary:
Remuneration according to the TVöD public sector up to pay grade 13 including attractive public-sector social security benefits.

Application deadline:
24.03.2024

Postdoc (f/m/x)

Aufgaben:
  • Decipher the role of posttranslational protein modifications, like oxidation, phosphorylation and acetylation, in environmental chemical exposed cell culture systems
  • Advance bioinformatic workflows for the analysis of proteomics/PTMomics data, including deep learning, network propagation or random forest modelling for the identification and prediction of cellular key events and drivers
  • Establishment and handling of single-cell proteomics workflows using the CellenONE F1.4
  • Active participation in laboratory group and department meetings, willingness to develop ideas for new research projects, and contribution to grant applications
  • Carry out collaborative projects with colleagues in partner institutions
Qualifikationsprofil:
  • PhD degree (or near completion) in biochemistry, molecular cell biology, immunology or related fields
  • Experience with mass spectrometry-based proteomics is a plus.
  • Programming skills with R.

Previous experience in one or more of the following is desired:

  • Experience in metabolic disruption and/or inflammation cell culture (immune cells and/or adipocytes or organoids
  • Knockdown/overexpression studies in eukaryotic system
  • Protein-protein interactions
  • Excellent communication skills
  • Ability to organize and prioritize work efficiently
  • Experience in supervision involving students and/or junior team members
  • Applications should be written in English
Benefits:
  • Excellent technical facilities which are without parallel
  • The freedom you need to bridge the difficult gap between basic research and close to being ready for application
  • Work in interdisciplinary, multinational teams and excellent links with national and international research networks
  • A vibrant region with a high quality of life and a wide cultural offering for a balance between family and professional life
  • Interesting career opportunities and an extensive range of training and further education courses

The UFZ has a strong commitment to diversity and actively supports equal opportunities for all employees regardless of their origin, religion, ideology, disability, age or romantic identity.
We look forward to applications from people who are open-minded and enjoy working in diverse teams.


Job tags

VollzeitPhD PositionPostdoc Stelle


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