Universität Erlangen-Nürnberg
Location
Erlangen | Germany
Job description
Our collegial and friendly research group (Prof. Hashemolhosseini, Chair Prof. Wegner) is interested in molecular physiological and pathophysiological aspects of skeletal muscle biology; in particular also muscular dystrophies, myopathies, myasthenias and muscle tumors (rhabdomyosarcoma).
Selected papers: - The YAP1/TAZ-TEAD transcriptional network regulates gene expression at neuromuscular junctions in skeletal muscle fibers. Gessler L, Huraskin D, Jian Y, Eiber N, Hu Z, Prószyński TJ, Hashemolhosseini S. Nucleic Acids Res. 2023 Dec 4:gkad1124. doi: 10.1093/nar/gkad1124. - In Adult Skeletal Muscles, the Co-Receptors of Canonical Wnt Signaling, Lrp5 and Lrp6, Determine the Distribution and Size of Fiber Types, and Structure and Function of Neuromuscular Junctions. Gessler L, Kurtek C, Merholz M, Jian Y, Hashemolhosseini S. Cells. 2022 Dec 8;11(24):3968. doi: 10.3390/cells1124396- In mammalian skeletal muscle, phosphorylation of TOMM22 by protein kinase CSNK2/CK2 controls mitophagy. Kravic B, Harbauer AB, Romanello V, Simeone L, Vögtle FN, Kaiser T, Straubinger M, Huraskin D, Böttcher M, Cerqua C, Martin ED, Poveda-Huertes D, Buttgereit A, Rabalski AJ, Heuss D, Rudolf R, Friedrich O, Litchfield D, Marber M, Salviati L, Mougiakakos D, Neuhuber W, Sandri M, Meisinger C, Hashemolhosseini S. Autophagy. 2018;14(2):311-335. doi: 10.1080/15548627.2017.1403716. Epub 2018 Feb 1. - Wnt/β-catenin signaling via Axin2 is required for myogenesis and, together with YAP/Taz and Tead1, active in IIa/IIx muscle fibers. Huraskin D, Eiber N, Reichel M, Zidek LM, Kravic B, Bernkopf D, von Maltzahn J, Behrens J, Hashemolhosseini S. Development. 2016 Sep 1;143(17):3128-42. doi: 10.1242/dev.139907. Aufgaben:Job tags
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