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Location

Bonn | Germany

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Job description

The Capasso lab is interested in how myeloid immune cells change with age and the impact this has on neurodegenerative diseases.

We are studying proteins regulating immune cell activation and how their loss can affect microglia response to amyloid plaque deposition, a hallmark of Alzheimer’s pathology. One of these proteins is the voltage-gated proton channel HVCN1, expressed by microglia and other immune cells. HVCN1 regulates immune cell ROS production (Capasso et al., Nat Immunol., 2010; Hondares et al., PNAS, 2014; Coe et al., JCI Insight, 2022) and we are investigating the effect of its loss in Alzheimer’s mouse models

PhD Student (f/m/x) in microglia biology in Alzheimer’s 1283/2024/2

Aufgaben:

We are seeking a PhD student with a strong interest in neurodegeneration who wants to study molecular aspect of microglia phenotypes as well in vivo behaviour in preclinical models.

Profil:

Enthusiastic, organised and pro-active PhD candidate with a degree in a relevant biomedical subject, such as neuroscience, immunology, molecular biology or biochemistry. Previous experience with preclinical models of neurodegeneration and Alzheimer’s disease will be a bonus, as well as previous experience working on microglia and/or having acquired basic bioinformatics skills.

We offer

• An interesting and challenging task in a research center that works on the future topics of health research
• An international environment characterized by a strong focus on science and research
• Options for the realization of family-friendly and flexible working conditions
• Targeted personnel development
• Initially limited to 2 years, with the possibility of extension
• Employment, payment and social benefits are determined by the Public Sector Collective Agreement (Tarifvertrag für den öffentlichen Dienst – TVöD Bund).

For informal enquires about the project, please contact Dr Melania Capasso:

We look forward to receiving your complete application documents, which include a letter of motivation and a curriculum vitae.

The DZNE is an equal opportunity employer. It is committed to employing disabled individuals and especially encourages them to apply.

You will obtain special skills and knowledge for your scientific qualification during your activities at DZNE

Kategorie: WissenschaftVertrag: 2 years, extension possibleAbteilung: Dr. Melania CapassoTyp: full-time

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Salary