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Location

Gelsenkirchen | Germany

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Job description

We are one of the youngest universities in Germany and think in terms of possibilities, not boundaries. In the heart of the Ruhr region, we develop ideas for the future at our 11 faculties. We are strong in research and teaching, embrace diversity, promote potential and are committed to educational equality worthy of the name.

At the Institute of Medical Microbiology, University Hospital Essen, in the group of Prof. Dr. Astrid M. Westendorf the following position (E 13 TV-L, 65 %) associated with the DFG-funded Research Training Group 2989 (RTG 2989) is available from the 1st of April 2024: Aufgaben:
Patients with acute myocardial infarction often exhibit dysbiosis, linked to poorer outcomes and severity of cardiovascular disease. Experimental studies on cerebral ischemia suggest ischemic events induce significant gut dysbiosis, potentially impacting the cardiovascular system. However, a comparable gut-heart axis pathomechanism for reperfused acute myocardial infarction is unknown. The project aims to analyze how reperfused acute myocardial infarction affects the murine intestinal microbiome. Key objectives include characterizing microbiome changes, studying active modulation effects (Germfree mice, antibiotic treatment, or dietary intervention) on cardiovascular dysfunction, and exploring the influence of bacterial metabolites on vascular integrity and immune cell function.

The RTG 2989 focuses on exploring distinct cellular interfaces in reperfused acute myocardial infarction, encompassing the immune system, vasculature, and cardiomyocytes. Its objective is to identify novel treatment options for myocardial infarction patients. To ensure comprehensive training, the RTG 2989 integrates cardiovascular scientists with researchers from infection/immunology. The RTG 2989 introduces a unique program cultivating doctoral students' clinical and basic scientific skills for successful research. Key features include standardized animal models, patient cohorts supervised by the Cardiac Trial Unit, Tandem supervison pairing clinicians with basic scientist, and a mentoring program. Qualifikationsprofil:

• Talented and enthusiastic with high interest in the research topic of RTG 2989
• Strong Diploma/Master degree in Biology, Experimental Medicine, or related fields
• High motivation and commitment for active cross-disciplinary collaboration
• Abilities for problem-solving and independent work
• Knowledge in cellular/molecular immunology, experience in FACS and cell culture
• Fluent in spoken and written English (knowledge of German is not a requirement)
• disposed to work with laboratory animals
• Very good skills in independent working, organization, communication, and team work
• Active participation in the RTG program

Benefits:

• Innovative cross-disciplinary scientific training for PhD and MD students at the interface between cardiovascular research and infection/immunology
• Training in transferable academic and soft skills
• Funding for active participation in workshops and conferences and international visits to collaboration partners
• Regular supervision and mentoring
• Excellent career opportunities
• Interdisciplinary work with colleagues from other departments
• Working with modern equipment and certified quality standards
• Family-friendly corporate culture

The pay grade classification depends on the personal and collective legal requirements. The salary is in accordance with the German public service salary scale. The position is third-party funded for the duration of 48 months.

Application details:

Interested candidates should fill in the application form and send it together with your curriculum vitae, covering letter, two reference letters and copies of all performance records, employment certificates and all university degrees in one pdf file only within 2 weeks after publication via [email protected] . Please refer to the application ID 10780 in the subject line. Only applications that fulfill all the formal requirements will be considered!

The University Hospital Essen is an equal opportunity employer. Female scientists are particularly encouraged to apply. The participation in secondary employment depends on the „Hochschulnebentätigkeitsverordnung“ of North-Rhine Westphalia. Disabled applicants will be preferentially considered in case of equivalent qualification.

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